Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show...

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Main Authors:	Virginie Mansuy-Aubert, Laurent Gautron, Syann Lee, Angie L Bookout, Christine M Kusminski, Kai Sun, Yuan Zhang, Philipp E Scherer, David J Mangelsdorf, Joel K Elmquist
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2015-06-01
Series:	eLife
Subjects:	nuclear receptor sensory neuron energy expenditure
Online Access:	https://elifesciences.org/articles/06667

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spelling	doaj-eb47156db2604f869ab1e9ff969d86a62021-05-04T23:51:19ZengeLife Sciences Publications LtdeLife2050-084X2015-06-01410.7554/eLife.06667Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditureVirginie Mansuy-Aubert0Laurent Gautron1Syann Lee2Angie L Bookout3Christine M Kusminski4Kai Sun5Yuan Zhang6Philipp E Scherer7David J Mangelsdorf8https://orcid.org/0000-0002-4355-0796Joel K Elmquist9Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, United States; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United StatesDivision of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, United States; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United StatesDivision of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, United States; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United StatesDepartment of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United StatesDepartment of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United StatesDepartment of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United StatesDivision of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, United States; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States; Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United StatesPeripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.https://elifesciences.org/articles/06667nuclear receptorsensory neuronenergy expenditure
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Virginie Mansuy-Aubert Laurent Gautron Syann Lee Angie L Bookout Christine M Kusminski Kai Sun Yuan Zhang Philipp E Scherer David J Mangelsdorf Joel K Elmquist
spellingShingle	Virginie Mansuy-Aubert Laurent Gautron Syann Lee Angie L Bookout Christine M Kusminski Kai Sun Yuan Zhang Philipp E Scherer David J Mangelsdorf Joel K Elmquist Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure eLife nuclear receptor sensory neuron energy expenditure
author_facet	Virginie Mansuy-Aubert Laurent Gautron Syann Lee Angie L Bookout Christine M Kusminski Kai Sun Yuan Zhang Philipp E Scherer David J Mangelsdorf Joel K Elmquist
author_sort	Virginie Mansuy-Aubert
title	Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title_short	Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title_full	Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title_fullStr	Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title_full_unstemmed	Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure
title_sort	loss of the liver x receptor lxrα/β in peripheral sensory neurons modifies energy expenditure
publisher	eLife Sciences Publications Ltd
series	eLife
issn	2050-084X
publishDate	2015-06-01
description	Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.
topic	nuclear receptor sensory neuron energy expenditure
url	https://elifesciences.org/articles/06667
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Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

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