Presynaptic translation: stepping out of the postsynaptic shadow
The ability of the nervous system to convert transient experiences into long-lasting structural changes at the synapse relies upon protein synthesis. It has become increasingly clear that a critical subset of this synthesis occurs within the synaptic compartment. While this process has been extensiv...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2009-11-01
|
Series: | Frontiers in Neural Circuits |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.04.017.2009/full |
id |
doaj-eb4ebe03eee641c8885b1b6921e891ea |
---|---|
record_format |
Article |
spelling |
doaj-eb4ebe03eee641c8885b1b6921e891ea2020-11-24T22:40:09ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102009-11-01310.3389/neuro.04.017.2009851Presynaptic translation: stepping out of the postsynaptic shadowMichael R Akins0Hanna E Berk-Rauch1Justin Fallon2Brown UniversityBrown UniversityBrown UniversityThe ability of the nervous system to convert transient experiences into long-lasting structural changes at the synapse relies upon protein synthesis. It has become increasingly clear that a critical subset of this synthesis occurs within the synaptic compartment. While this process has been extensively characterized in the postsynaptic compartment, the contribution of local translation to presynaptic function remains largely unexplored. However, recent evidence highlights the potential importance of translation within the presynaptic compartment. Work in cultured neurons has shown that presynaptic translation occurs specifically at synapses undergoing long-term plasticity and may contribute to the maintenance of nascent synapses. Studies from our laboratory have demonstrated that Fragile X proteins, which regulate mRNA localization and translation, are expressed at the presynaptic apparatus. Further, mRNAs encoding presynaptic proteins traffic into axons. Here we discuss recent advances in the study of presynaptic translation as well as the challenges confronting the field. Understanding the regulation of presynaptic function by local protein synthesis promises to shed new light on activity-dependent modification of synaptic architecture.http://journal.frontiersin.org/Journal/10.3389/neuro.04.017.2009/fullFragile X SyndromeautismmRNAsynaptic plasticitylocal translationmTOR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael R Akins Hanna E Berk-Rauch Justin Fallon |
spellingShingle |
Michael R Akins Hanna E Berk-Rauch Justin Fallon Presynaptic translation: stepping out of the postsynaptic shadow Frontiers in Neural Circuits Fragile X Syndrome autism mRNA synaptic plasticity local translation mTOR |
author_facet |
Michael R Akins Hanna E Berk-Rauch Justin Fallon |
author_sort |
Michael R Akins |
title |
Presynaptic translation: stepping out of the postsynaptic shadow |
title_short |
Presynaptic translation: stepping out of the postsynaptic shadow |
title_full |
Presynaptic translation: stepping out of the postsynaptic shadow |
title_fullStr |
Presynaptic translation: stepping out of the postsynaptic shadow |
title_full_unstemmed |
Presynaptic translation: stepping out of the postsynaptic shadow |
title_sort |
presynaptic translation: stepping out of the postsynaptic shadow |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neural Circuits |
issn |
1662-5110 |
publishDate |
2009-11-01 |
description |
The ability of the nervous system to convert transient experiences into long-lasting structural changes at the synapse relies upon protein synthesis. It has become increasingly clear that a critical subset of this synthesis occurs within the synaptic compartment. While this process has been extensively characterized in the postsynaptic compartment, the contribution of local translation to presynaptic function remains largely unexplored. However, recent evidence highlights the potential importance of translation within the presynaptic compartment. Work in cultured neurons has shown that presynaptic translation occurs specifically at synapses undergoing long-term plasticity and may contribute to the maintenance of nascent synapses. Studies from our laboratory have demonstrated that Fragile X proteins, which regulate mRNA localization and translation, are expressed at the presynaptic apparatus. Further, mRNAs encoding presynaptic proteins traffic into axons. Here we discuss recent advances in the study of presynaptic translation as well as the challenges confronting the field. Understanding the regulation of presynaptic function by local protein synthesis promises to shed new light on activity-dependent modification of synaptic architecture. |
topic |
Fragile X Syndrome autism mRNA synaptic plasticity local translation mTOR |
url |
http://journal.frontiersin.org/Journal/10.3389/neuro.04.017.2009/full |
work_keys_str_mv |
AT michaelrakins presynaptictranslationsteppingoutofthepostsynapticshadow AT hannaeberkrauch presynaptictranslationsteppingoutofthepostsynapticshadow AT justinfallon presynaptictranslationsteppingoutofthepostsynapticshadow |
_version_ |
1725705701051858944 |