Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screening
Abstract Background Some evidence has shown that malignant breast tumours have lower electrical impedance than surrounding normal tissues. Electrical impedance could be used as an indicator for breast cancer detection. The purpose of our study was to analyse the sensitivity and specificity of electr...
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doaj-eb5ddeef63d2499faef1434d1ca9b53a2020-11-25T02:12:57ZengBMCBMC Cancer1471-24072020-09-0120111010.1186/s12885-020-07283-5Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screeningBlanca Murillo-Ortiz0Abraham Hernández-Ramírez1Talia Rivera-Villanueva2David Suárez-García3Mario Murguía-Pérez4Sandra Martínez-Garza5Allyson Rodríguez-Penin6Rosario Romero-Coripuna7Xiomara Midory López-Partida8Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajío, Instituto Mexicano del Seguro SocialServicio de Radiología e Imagen Unidad Médica de Alta Especialidad No. 48, Instituto Mexicano del Seguro SocialDepartamento de Radiología, Hospital General de Zona No. 58, Delegación Guanajuato, Instituto Mexicano del Seguro SocialDepartamento de Oncología, Unidad Médica de Alta Especialidad No. 1 BajíoDepartamento de Patología, Unidad Médica de Alta Especialidad No. 1 Bajío, Instituto Mexicano del Seguro SocialUnidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajío, Instituto Mexicano del Seguro SocialUnidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajío, Instituto Mexicano del Seguro SocialUnidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajío, Instituto Mexicano del Seguro SocialUnidad de Medicina Familiar No. 51, Delegación Guanajuato, Instituto Mexicano del Seguro SocialAbstract Background Some evidence has shown that malignant breast tumours have lower electrical impedance than surrounding normal tissues. Electrical impedance could be used as an indicator for breast cancer detection. The purpose of our study was to analyse the sensitivity and specificity of electrical impedance mammography (EIM) and its implementation for the differential diagnosis of pathological lesions of the breast, either alone or in combination with mammography/ultrasound, in 1200 women between 25 and 70 years old. Methods This study is a prospective, cross-sectional epidemiological observational study of serial screening. The women were invited to participate and signed a consent letter. Impedance imaging of the mammary gland was evaluated with the computerized mammography equipment of MEIK electroimpedance v.5.6. (0.5 mA, 50 kHz), developed and manufactured by PKF SIM-Technika®. The successful identification of breast cancer along with the sensitivity, specificity, and positive and negative predictive values of EIM were determined as follows: % sensitivity; % specificity; % positive predictive value (PPV); and % negative predictive value (NPV). Results EIM had a sensitivity of 85% and a specificity of 96%; the positive predictive value was 12%, and the negative predictive value was 99%. Seven cases were biopsy confirmed cancers. Significant correlations between the electrical conductivity index and body mass index (BMI) (p = 0.04) and patient age were observed (p = 0.01). We also observed that the average conductivity distribution increased according to age group (p = 0.001). We used the chi-squared test to assess the interactions between percent density and BMI (normal < 25 kg/m2 (n = 310), overweight 25–29.9 kg/m2 (n = 418) and obese ≥30 (n = 437)) (p < 0.05). The patients with a diagnosis of mammary carcinoma had a BMI of 35.51 kg/m2. Conclusions Our results demonstrate that the use of monofrequency electrical impedance mammography (EIM) in the detection of breast cancer had a sensitivity and specificity of 85 and 96%, respectively. These findings may support future research in the early detection of breast cancer. EIM is a non-radiation method that may also be used as a screening method for young women with dense breasts and a high risk of developing breast cancer.http://link.springer.com/article/10.1186/s12885-020-07283-5Breast cancerScreeningFrequency electrical impedance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Blanca Murillo-Ortiz Abraham Hernández-Ramírez Talia Rivera-Villanueva David Suárez-García Mario Murguía-Pérez Sandra Martínez-Garza Allyson Rodríguez-Penin Rosario Romero-Coripuna Xiomara Midory López-Partida |
spellingShingle |
Blanca Murillo-Ortiz Abraham Hernández-Ramírez Talia Rivera-Villanueva David Suárez-García Mario Murguía-Pérez Sandra Martínez-Garza Allyson Rodríguez-Penin Rosario Romero-Coripuna Xiomara Midory López-Partida Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screening BMC Cancer Breast cancer Screening Frequency electrical impedance |
author_facet |
Blanca Murillo-Ortiz Abraham Hernández-Ramírez Talia Rivera-Villanueva David Suárez-García Mario Murguía-Pérez Sandra Martínez-Garza Allyson Rodríguez-Penin Rosario Romero-Coripuna Xiomara Midory López-Partida |
author_sort |
Blanca Murillo-Ortiz |
title |
Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screening |
title_short |
Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screening |
title_full |
Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screening |
title_fullStr |
Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screening |
title_full_unstemmed |
Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screening |
title_sort |
monofrequency electrical impedance mammography (eim) diagnostic system in breast cancer screening |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2020-09-01 |
description |
Abstract Background Some evidence has shown that malignant breast tumours have lower electrical impedance than surrounding normal tissues. Electrical impedance could be used as an indicator for breast cancer detection. The purpose of our study was to analyse the sensitivity and specificity of electrical impedance mammography (EIM) and its implementation for the differential diagnosis of pathological lesions of the breast, either alone or in combination with mammography/ultrasound, in 1200 women between 25 and 70 years old. Methods This study is a prospective, cross-sectional epidemiological observational study of serial screening. The women were invited to participate and signed a consent letter. Impedance imaging of the mammary gland was evaluated with the computerized mammography equipment of MEIK electroimpedance v.5.6. (0.5 mA, 50 kHz), developed and manufactured by PKF SIM-Technika®. The successful identification of breast cancer along with the sensitivity, specificity, and positive and negative predictive values of EIM were determined as follows: % sensitivity; % specificity; % positive predictive value (PPV); and % negative predictive value (NPV). Results EIM had a sensitivity of 85% and a specificity of 96%; the positive predictive value was 12%, and the negative predictive value was 99%. Seven cases were biopsy confirmed cancers. Significant correlations between the electrical conductivity index and body mass index (BMI) (p = 0.04) and patient age were observed (p = 0.01). We also observed that the average conductivity distribution increased according to age group (p = 0.001). We used the chi-squared test to assess the interactions between percent density and BMI (normal < 25 kg/m2 (n = 310), overweight 25–29.9 kg/m2 (n = 418) and obese ≥30 (n = 437)) (p < 0.05). The patients with a diagnosis of mammary carcinoma had a BMI of 35.51 kg/m2. Conclusions Our results demonstrate that the use of monofrequency electrical impedance mammography (EIM) in the detection of breast cancer had a sensitivity and specificity of 85 and 96%, respectively. These findings may support future research in the early detection of breast cancer. EIM is a non-radiation method that may also be used as a screening method for young women with dense breasts and a high risk of developing breast cancer. |
topic |
Breast cancer Screening Frequency electrical impedance |
url |
http://link.springer.com/article/10.1186/s12885-020-07283-5 |
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