Bergamot Polyphenol Fraction Exerts Effects on Bone Biology by Activating ERK 1/2 and Wnt/β-Catenin Pathway and Regulating Bone Biomarkers in Bone Cell Cultures

Bergamot Polyphenol Fraction Exerts Effects on Bone Biology by Activating ERK 1/2 and Wnt/β-Catenin Pathway and Regulating Bone Biomarkers in Bone Cell Cultures

Epidemiological studies show that fruit consumption may modulate bone mineral density. However, data regarding the effect of the Citrus bergamia Risso (Bergamot orange), a citrus fruit containing a high concentration of flavonoids, on bone health are still lacking. In this study, we investigated the...

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Bibliographic Details
Main Authors: Arturo Pujia, Cristina Russo, Samantha Maurotti, Roberta Pujia, Vincenzo Mollace, Stefano Romeo, Tiziana Montalcini
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Nutrients
Subjects:
polyphenols
citrus fruits
Bergamot
osteoporosis
Saos-2
bone cells
β-catenin
Online Access:http://www.mdpi.com/2072-6643/10/9/1305

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