Receptor Binding Domains of TcdB from <i>Clostridioides difficile</i> for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive
Toxin B (TcdB) produced by <i>Clostridioides difficile</i> is a main pathogenicity factor that affects a variety of different cell types within the colonic mucosa. TcdB is known to utilize frizzled-1,2,7 and chondroitin sulfate proteoglycan-4 (CSPG4) as protein receptors. By using human...
Main Authors: | Daniel Henkel, Helma Tatge, Dennis Schöttelndreier, Liang Tao, Min Dong, Ralf Gerhard |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
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Series: | Toxins |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6651/12/12/736 |
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