Synthetic hydrogel nanoparticles for sepsis therapy

Sepsis caused by the release of inflammatory mediators into the blood is a life threatening disease. Here, the authors report on the development of hydrogel nanoparticles for the capture and neutralisation of histones, major inflammatory mediators, and demonstrate sepsis treatment in a murine model.

Bibliographic Details
Main Authors:	Hiroyuki Koide, Anna Okishima, Yu Hoshino, Yuri Kamon, Keiichi Yoshimatsu, Kazuhiro Saito, Ikumi Yamauchi, Saki Ariizumi, Yuqi Zhou, Ting-Hui Xiao, Keisuke Goda, Naoto Oku, Tomohiro Asai, Kenneth J. Shea
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25847-2

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spelling	doaj-eb612ef6ea67468793984170be09b6f22021-09-26T11:44:52ZengNature Publishing GroupNature Communications2041-17232021-09-0112111410.1038/s41467-021-25847-2Synthetic hydrogel nanoparticles for sepsis therapyHiroyuki Koide0Anna Okishima1Yu Hoshino2Yuri Kamon3Keiichi Yoshimatsu4Kazuhiro Saito5Ikumi Yamauchi6Saki Ariizumi7Yuqi Zhou8Ting-Hui Xiao9Keisuke Goda10Naoto Oku11Tomohiro Asai12Kenneth J. Shea13Department of Medical Biochemistry, University of ShizuokaDepartment of Medical Biochemistry, University of ShizuokaDepartment of Chemical Engineering, Kyushu UniversityDepartment of Chemistry, University of California IrvineDepartment of Chemistry, University of California IrvineDepartment of Medical Biochemistry, University of ShizuokaDepartment of Medical Biochemistry, University of ShizuokaDepartment of Medical Biochemistry, University of ShizuokaDepartment of Chemistry, The University of TokyoDepartment of Chemistry, The University of TokyoDepartment of Chemistry, The University of TokyoDepartment of Medical Biochemistry, University of ShizuokaDepartment of Medical Biochemistry, University of ShizuokaDepartment of Chemistry, University of California IrvineSepsis caused by the release of inflammatory mediators into the blood is a life threatening disease. Here, the authors report on the development of hydrogel nanoparticles for the capture and neutralisation of histones, major inflammatory mediators, and demonstrate sepsis treatment in a murine model.https://doi.org/10.1038/s41467-021-25847-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hiroyuki Koide Anna Okishima Yu Hoshino Yuri Kamon Keiichi Yoshimatsu Kazuhiro Saito Ikumi Yamauchi Saki Ariizumi Yuqi Zhou Ting-Hui Xiao Keisuke Goda Naoto Oku Tomohiro Asai Kenneth J. Shea
spellingShingle	Hiroyuki Koide Anna Okishima Yu Hoshino Yuri Kamon Keiichi Yoshimatsu Kazuhiro Saito Ikumi Yamauchi Saki Ariizumi Yuqi Zhou Ting-Hui Xiao Keisuke Goda Naoto Oku Tomohiro Asai Kenneth J. Shea Synthetic hydrogel nanoparticles for sepsis therapy Nature Communications
author_facet	Hiroyuki Koide Anna Okishima Yu Hoshino Yuri Kamon Keiichi Yoshimatsu Kazuhiro Saito Ikumi Yamauchi Saki Ariizumi Yuqi Zhou Ting-Hui Xiao Keisuke Goda Naoto Oku Tomohiro Asai Kenneth J. Shea
author_sort	Hiroyuki Koide
title	Synthetic hydrogel nanoparticles for sepsis therapy
title_short	Synthetic hydrogel nanoparticles for sepsis therapy
title_full	Synthetic hydrogel nanoparticles for sepsis therapy
title_fullStr	Synthetic hydrogel nanoparticles for sepsis therapy
title_full_unstemmed	Synthetic hydrogel nanoparticles for sepsis therapy
title_sort	synthetic hydrogel nanoparticles for sepsis therapy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-09-01
description	Sepsis caused by the release of inflammatory mediators into the blood is a life threatening disease. Here, the authors report on the development of hydrogel nanoparticles for the capture and neutralisation of histones, major inflammatory mediators, and demonstrate sepsis treatment in a murine model.
url	https://doi.org/10.1038/s41467-021-25847-2
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Synthetic hydrogel nanoparticles for sepsis therapy

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