Glucose metabolism induced by Bmp signaling is essential for murine skeletal development

Glucose metabolism induced by Bmp signaling is essential for murine skeletal development

It is unclear how metabolic regulation affects development of the skeleton. Here, the authors show that deletion of the glucose transporter Glut1 (Slc2a1) both prior to and following chondrogenesis in the mouse limb impairs chondrocyte proliferation and shortening of the limbs, modulated by BMP sign...

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Main Authors: Seung-Yon Lee, E. Dale Abel, Fanxin Long
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07316-5
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spelling doaj-eb7aa659cfbd46fab6e60c1ebb511dcd2021-05-11T09:29:05ZengNature Publishing GroupNature Communications2041-17232018-11-019111110.1038/s41467-018-07316-5Glucose metabolism induced by Bmp signaling is essential for murine skeletal developmentSeung-Yon Lee0E. Dale Abel1Fanxin Long2Department of Orthopaedic Surgery, Washington University School of MedicineFraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Carver College of Medicine, University of IowaDepartment of Orthopaedic Surgery, Washington University School of MedicineIt is unclear how metabolic regulation affects development of the skeleton. Here, the authors show that deletion of the glucose transporter Glut1 (Slc2a1) both prior to and following chondrogenesis in the mouse limb impairs chondrocyte proliferation and shortening of the limbs, modulated by BMP signaling.https://doi.org/10.1038/s41467-018-07316-5
collection DOAJ
language English
format Article
sources DOAJ
author Seung-Yon Lee
E. Dale Abel
Fanxin Long
spellingShingle Seung-Yon Lee
E. Dale Abel
Fanxin Long
Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
Nature Communications
author_facet Seung-Yon Lee
E. Dale Abel
Fanxin Long
author_sort Seung-Yon Lee
title Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
title_short Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
title_full Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
title_fullStr Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
title_full_unstemmed Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
title_sort glucose metabolism induced by bmp signaling is essential for murine skeletal development
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description It is unclear how metabolic regulation affects development of the skeleton. Here, the authors show that deletion of the glucose transporter Glut1 (Slc2a1) both prior to and following chondrogenesis in the mouse limb impairs chondrocyte proliferation and shortening of the limbs, modulated by BMP signaling.
url https://doi.org/10.1038/s41467-018-07316-5
work_keys_str_mv AT seungyonlee glucosemetabolisminducedbybmpsignalingisessentialformurineskeletaldevelopment
AT edaleabel glucosemetabolisminducedbybmpsignalingisessentialformurineskeletaldevelopment
AT fanxinlong glucosemetabolisminducedbybmpsignalingisessentialformurineskeletaldevelopment
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