Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
It is unclear how metabolic regulation affects development of the skeleton. Here, the authors show that deletion of the glucose transporter Glut1 (Slc2a1) both prior to and following chondrogenesis in the mouse limb impairs chondrocyte proliferation and shortening of the limbs, modulated by BMP sign...
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Nature Publishing Group
2018-11-01
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Online Access: | https://doi.org/10.1038/s41467-018-07316-5 |
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doaj-eb7aa659cfbd46fab6e60c1ebb511dcd2021-05-11T09:29:05ZengNature Publishing GroupNature Communications2041-17232018-11-019111110.1038/s41467-018-07316-5Glucose metabolism induced by Bmp signaling is essential for murine skeletal developmentSeung-Yon Lee0E. Dale Abel1Fanxin Long2Department of Orthopaedic Surgery, Washington University School of MedicineFraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Carver College of Medicine, University of IowaDepartment of Orthopaedic Surgery, Washington University School of MedicineIt is unclear how metabolic regulation affects development of the skeleton. Here, the authors show that deletion of the glucose transporter Glut1 (Slc2a1) both prior to and following chondrogenesis in the mouse limb impairs chondrocyte proliferation and shortening of the limbs, modulated by BMP signaling.https://doi.org/10.1038/s41467-018-07316-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seung-Yon Lee E. Dale Abel Fanxin Long |
spellingShingle |
Seung-Yon Lee E. Dale Abel Fanxin Long Glucose metabolism induced by Bmp signaling is essential for murine skeletal development Nature Communications |
author_facet |
Seung-Yon Lee E. Dale Abel Fanxin Long |
author_sort |
Seung-Yon Lee |
title |
Glucose metabolism induced by Bmp signaling is essential for murine skeletal development |
title_short |
Glucose metabolism induced by Bmp signaling is essential for murine skeletal development |
title_full |
Glucose metabolism induced by Bmp signaling is essential for murine skeletal development |
title_fullStr |
Glucose metabolism induced by Bmp signaling is essential for murine skeletal development |
title_full_unstemmed |
Glucose metabolism induced by Bmp signaling is essential for murine skeletal development |
title_sort |
glucose metabolism induced by bmp signaling is essential for murine skeletal development |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-11-01 |
description |
It is unclear how metabolic regulation affects development of the skeleton. Here, the authors show that deletion of the glucose transporter Glut1 (Slc2a1) both prior to and following chondrogenesis in the mouse limb impairs chondrocyte proliferation and shortening of the limbs, modulated by BMP signaling. |
url |
https://doi.org/10.1038/s41467-018-07316-5 |
work_keys_str_mv |
AT seungyonlee glucosemetabolisminducedbybmpsignalingisessentialformurineskeletaldevelopment AT edaleabel glucosemetabolisminducedbybmpsignalingisessentialformurineskeletaldevelopment AT fanxinlong glucosemetabolisminducedbybmpsignalingisessentialformurineskeletaldevelopment |
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1721449823752683520 |