Glucose metabolism induced by Bmp signaling is essential for murine skeletal development

It is unclear how metabolic regulation affects development of the skeleton. Here, the authors show that deletion of the glucose transporter Glut1 (Slc2a1) both prior to and following chondrogenesis in the mouse limb impairs chondrocyte proliferation and shortening of the limbs, modulated by BMP sign...

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Bibliographic Details
Main Authors: Seung-Yon Lee, E. Dale Abel, Fanxin Long
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07316-5

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