Genistein as a Potential Anticancer Agent against Ovarian Cancer
Genistein is known as the major component of isoflavone, which is present in high-soy diets. Genistein has received much attention because of its chemopreventive and therapeutic effects on various types of cancers. Numerous studies have shown that genistein has antineoplastic effects against ovarian...
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doaj-eb80edbb467240f1928cd24d21a96b742020-11-24T21:06:59ZengElsevierJournal of Traditional and Complementary Medicine2225-41102012-04-01229610410.1016/S2225-4110(16)30082-7Genistein as a Potential Anticancer Agent against Ovarian CancerJung-Yun Lee0Hee Seung Kim1Yong-Sang Song, MD, PhD2Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110-744, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110-744, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110-744, Republic of KoreaGenistein is known as the major component of isoflavone, which is present in high-soy diets. Genistein has received much attention because of its chemopreventive and therapeutic effects on various types of cancers. Numerous studies have shown that genistein has antineoplastic effects against ovarian cancer. Several epidemiological studies have shown that women who have high consumption of isoflavones have a relatively low incidence of ovarian cancer. Genistein inhibits ovarian carcinogenesis by pleiotropic mechanisms. A higher affinity to estrogen receptor β is one probable explanation for its ability to reduce the risk of ovarian cancer. Genistein also targets multiple cellular signal transduction pathways associated with cell cycle regulation and apoptosis. In addition, genistein has been suggested to have antiangiogenic and antioxidant activities. Herein, we summarize recent results from epidemiological and experimental studies to identify the role of genistein in ovarian cancer. Further studies are needed to achieve conclusive results and determine the clinical applications of genistein.http://www.sciencedirect.com/science/article/pii/S2225411016300827GenisteinIsoflavoneOvarian cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jung-Yun Lee Hee Seung Kim Yong-Sang Song, MD, PhD |
spellingShingle |
Jung-Yun Lee Hee Seung Kim Yong-Sang Song, MD, PhD Genistein as a Potential Anticancer Agent against Ovarian Cancer Journal of Traditional and Complementary Medicine Genistein Isoflavone Ovarian cancer |
author_facet |
Jung-Yun Lee Hee Seung Kim Yong-Sang Song, MD, PhD |
author_sort |
Jung-Yun Lee |
title |
Genistein as a Potential Anticancer Agent against Ovarian Cancer |
title_short |
Genistein as a Potential Anticancer Agent against Ovarian Cancer |
title_full |
Genistein as a Potential Anticancer Agent against Ovarian Cancer |
title_fullStr |
Genistein as a Potential Anticancer Agent against Ovarian Cancer |
title_full_unstemmed |
Genistein as a Potential Anticancer Agent against Ovarian Cancer |
title_sort |
genistein as a potential anticancer agent against ovarian cancer |
publisher |
Elsevier |
series |
Journal of Traditional and Complementary Medicine |
issn |
2225-4110 |
publishDate |
2012-04-01 |
description |
Genistein is known as the major component of isoflavone, which is present in high-soy diets. Genistein has received much attention because of its chemopreventive and therapeutic effects on various types of cancers. Numerous studies have shown that genistein has antineoplastic effects against ovarian cancer. Several epidemiological studies have shown that women who have high consumption of isoflavones have a relatively low incidence of ovarian cancer. Genistein inhibits ovarian carcinogenesis by pleiotropic mechanisms. A higher affinity to estrogen receptor β is one probable explanation for its ability to reduce the risk of ovarian cancer. Genistein also targets multiple cellular signal transduction pathways associated with cell cycle regulation and apoptosis. In addition, genistein has been suggested to have antiangiogenic and antioxidant activities. Herein, we summarize recent results from epidemiological and experimental studies to identify the role of genistein in ovarian cancer. Further studies are needed to achieve conclusive results and determine the clinical applications of genistein. |
topic |
Genistein Isoflavone Ovarian cancer |
url |
http://www.sciencedirect.com/science/article/pii/S2225411016300827 |
work_keys_str_mv |
AT jungyunlee genisteinasapotentialanticanceragentagainstovariancancer AT heeseungkim genisteinasapotentialanticanceragentagainstovariancancer AT yongsangsongmdphd genisteinasapotentialanticanceragentagainstovariancancer |
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