Artificial Sperm: New Horizons in Procreation
Azoospermia, the absence of any sperm cells from the ejaculated semen, poses a real challenge to the fertility urologist. While there are options to create happy families for azoospermic couples, such as the use of donor sperm and adoption, most couples still want to have genetically related offspri...
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doaj-eb87b8cfc9f4470a9a690a73ef46838f2020-11-24T21:29:09ZengRambam Health Care CampusRambam Maimonides Medical Journal2076-91722017-10-0184e004210.5041/RMMJ.10319Artificial Sperm: New Horizons in ProcreationValentin Shabataev0Raanan Tal1Department of Urology, Rambam Health Care Campus, Haifa, IsraelNeuro-Urology Unit, Rambam Health Care Campus, Haifa, IsraelAzoospermia, the absence of any sperm cells from the ejaculated semen, poses a real challenge to the fertility urologist. While there are options to create happy families for azoospermic couples, such as the use of donor sperm and adoption, most couples still want to have genetically related offspring. Advances in urology, gynecology, and fertility laboratory technologies allow surgical sperm retrieval in azoospermic men and achievement of live births for many, but not all azoospermic couples. At present, there are extensive research efforts in several directions to create new fertility options by creating “artificial sperm cells.” While these new horizons are exciting, there are significant obstacles that must be overcome before such innovative solutions can be offered to azoospermic couples. The present review article defines the problem, describes the theoretical basis for creation of artificial genetically related sperm cells, and provides an update on current successes and challenges in the long tortuous path to achieve the ultimate goal: enabling every azoospermic couple to have their own genetically related offspring. Hopefully, these research efforts will ripen in the foreseeable future, resulting in the ability to create artificial sperm cells and provide such couples with off-the-shelf solutions and fulfilling their desire to parent genetically related healthy babies.https://www.rmmj.org.il/issues/35/777/manuscriptArtificial spermazoospermiamale infertilityspermatogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Valentin Shabataev Raanan Tal |
spellingShingle |
Valentin Shabataev Raanan Tal Artificial Sperm: New Horizons in Procreation Rambam Maimonides Medical Journal Artificial sperm azoospermia male infertility spermatogenesis |
author_facet |
Valentin Shabataev Raanan Tal |
author_sort |
Valentin Shabataev |
title |
Artificial Sperm: New Horizons in Procreation |
title_short |
Artificial Sperm: New Horizons in Procreation |
title_full |
Artificial Sperm: New Horizons in Procreation |
title_fullStr |
Artificial Sperm: New Horizons in Procreation |
title_full_unstemmed |
Artificial Sperm: New Horizons in Procreation |
title_sort |
artificial sperm: new horizons in procreation |
publisher |
Rambam Health Care Campus |
series |
Rambam Maimonides Medical Journal |
issn |
2076-9172 |
publishDate |
2017-10-01 |
description |
Azoospermia, the absence of any sperm cells from the ejaculated semen, poses a real challenge to the fertility urologist. While there are options to create happy families for azoospermic couples, such as the use of donor sperm and adoption, most couples still want to have genetically related offspring. Advances in urology, gynecology, and fertility laboratory technologies allow surgical sperm retrieval in azoospermic men and achievement of live births for many, but not all azoospermic couples. At present, there are extensive research efforts in several directions to create new fertility options by creating “artificial sperm cells.” While these new horizons are exciting, there are significant obstacles that must be overcome before such innovative solutions can be offered to azoospermic couples. The present review article defines the problem, describes the theoretical basis for creation of artificial genetically related sperm cells, and provides an update on current successes and challenges in the long tortuous path to achieve the ultimate goal: enabling every azoospermic couple to have their own genetically related offspring. Hopefully, these research efforts will ripen in the foreseeable future, resulting in the ability to create artificial sperm cells and provide such couples with off-the-shelf solutions and fulfilling their desire to parent genetically related healthy babies. |
topic |
Artificial sperm azoospermia male infertility spermatogenesis |
url |
https://www.rmmj.org.il/issues/35/777/manuscript |
work_keys_str_mv |
AT valentinshabataev artificialspermnewhorizonsinprocreation AT raanantal artificialspermnewhorizonsinprocreation |
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