Retrospective observational study of salvage line ramucirumab monotherapy for patients with advanced gastric cancer
Abstract Background Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes used as third- or later-line treatment for AGC refractory to fluoropyri...
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doaj-eb8b100e1efb473587bd1cadee493b612020-11-25T02:59:50ZengBMCBMC Cancer1471-24072020-04-012011910.1186/s12885-020-06865-7Retrospective observational study of salvage line ramucirumab monotherapy for patients with advanced gastric cancerSadayuki Kawai0Naoki Fukuda1Shun Yamamoto2Seiichiro Mitani3Katsuhiro Omae4Takeru Wakatsuki5Ken Kato6Shigenori Kadowaki7Daisuke Takahari8Narikazu Boku9Kei Muro10Nozomu Machida11Division of Gastrointestinal Oncology, Shizuoka Cancer CenterDepartment of Gastroenterology, Cancer Institute Hospital of Japanese Foundation For Cancer ResearchDivision of Gastrointestinal Medical Oncology, National Cancer Center HospitalDepartment of Clinical Oncology, Aichi Cancer Center HospitalClinical Research Center, Shizuoka Cancer CenterDepartment of Gastroenterology, Cancer Institute Hospital of Japanese Foundation For Cancer ResearchDivision of Gastrointestinal Medical Oncology, National Cancer Center HospitalDepartment of Clinical Oncology, Aichi Cancer Center HospitalDepartment of Gastroenterology, Cancer Institute Hospital of Japanese Foundation For Cancer ResearchDivision of Gastrointestinal Medical Oncology, National Cancer Center HospitalDepartment of Clinical Oncology, Aichi Cancer Center HospitalDivision of Gastrointestinal Oncology, Shizuoka Cancer CenterAbstract Background Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes used as third- or later-line treatment for AGC refractory to fluoropyrimidine and taxanes. This study evaluated the efficacy and safety of salvage-line ramucirumab monotherapy for treating AGC. Methods The subjects of this retrospective study were advanced gastric or gastro-esophageal junction adenocarcinoma patients who received ramucirumab monotherapy after failure of 2 or more prior regimens containing fluoropyrimidine and taxanes but not ramucirumab. Results From June 2015 to April 2017, 51 patients were enrolled. The median progression-free survival (PFS) and overall survival (OS) were 1.8 (95% confidence interval [CI] = 1.6–2.2) and 5.1 (95% CI = 4.0–6.8) months, respectively. The objective response and disease control rates were 2 and 17%, respectively. Grade 3 adverse events (AEs; e.g., anemia, fatigue, hypertension, proteinuria, intestinal bleeding) occurred in seven (13%) patients, but no grade 4 AEs and treatment-related deaths were observed. A neutrophil–lymphocyte ratio (NLR) of < 2.5 and previous gastrectomy were associated with better PFS. Conclusions Salvage-line ramucirumab monotherapy has acceptable toxicity and comparable efficacy to second-line treatment; therefore, we consider physicians might choose this therapy as a salvage-line treatment option for AGC refractory to the standard therapies.http://link.springer.com/article/10.1186/s12885-020-06865-7Stomach neoplasmsDrug therapySalvage therapyRamucirumab |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sadayuki Kawai Naoki Fukuda Shun Yamamoto Seiichiro Mitani Katsuhiro Omae Takeru Wakatsuki Ken Kato Shigenori Kadowaki Daisuke Takahari Narikazu Boku Kei Muro Nozomu Machida |
spellingShingle |
Sadayuki Kawai Naoki Fukuda Shun Yamamoto Seiichiro Mitani Katsuhiro Omae Takeru Wakatsuki Ken Kato Shigenori Kadowaki Daisuke Takahari Narikazu Boku Kei Muro Nozomu Machida Retrospective observational study of salvage line ramucirumab monotherapy for patients with advanced gastric cancer BMC Cancer Stomach neoplasms Drug therapy Salvage therapy Ramucirumab |
author_facet |
Sadayuki Kawai Naoki Fukuda Shun Yamamoto Seiichiro Mitani Katsuhiro Omae Takeru Wakatsuki Ken Kato Shigenori Kadowaki Daisuke Takahari Narikazu Boku Kei Muro Nozomu Machida |
author_sort |
Sadayuki Kawai |
title |
Retrospective observational study of salvage line ramucirumab monotherapy for patients with advanced gastric cancer |
title_short |
Retrospective observational study of salvage line ramucirumab monotherapy for patients with advanced gastric cancer |
title_full |
Retrospective observational study of salvage line ramucirumab monotherapy for patients with advanced gastric cancer |
title_fullStr |
Retrospective observational study of salvage line ramucirumab monotherapy for patients with advanced gastric cancer |
title_full_unstemmed |
Retrospective observational study of salvage line ramucirumab monotherapy for patients with advanced gastric cancer |
title_sort |
retrospective observational study of salvage line ramucirumab monotherapy for patients with advanced gastric cancer |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2020-04-01 |
description |
Abstract Background Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes used as third- or later-line treatment for AGC refractory to fluoropyrimidine and taxanes. This study evaluated the efficacy and safety of salvage-line ramucirumab monotherapy for treating AGC. Methods The subjects of this retrospective study were advanced gastric or gastro-esophageal junction adenocarcinoma patients who received ramucirumab monotherapy after failure of 2 or more prior regimens containing fluoropyrimidine and taxanes but not ramucirumab. Results From June 2015 to April 2017, 51 patients were enrolled. The median progression-free survival (PFS) and overall survival (OS) were 1.8 (95% confidence interval [CI] = 1.6–2.2) and 5.1 (95% CI = 4.0–6.8) months, respectively. The objective response and disease control rates were 2 and 17%, respectively. Grade 3 adverse events (AEs; e.g., anemia, fatigue, hypertension, proteinuria, intestinal bleeding) occurred in seven (13%) patients, but no grade 4 AEs and treatment-related deaths were observed. A neutrophil–lymphocyte ratio (NLR) of < 2.5 and previous gastrectomy were associated with better PFS. Conclusions Salvage-line ramucirumab monotherapy has acceptable toxicity and comparable efficacy to second-line treatment; therefore, we consider physicians might choose this therapy as a salvage-line treatment option for AGC refractory to the standard therapies. |
topic |
Stomach neoplasms Drug therapy Salvage therapy Ramucirumab |
url |
http://link.springer.com/article/10.1186/s12885-020-06865-7 |
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