Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

Summary: Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum circumsporozoite protein (CSPRepeat) can protect against malaria. However, it has also been suggested that the CSPRepeat is a decoy that prevents the immune system from mounting responses against other domains of...

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Bibliographic Details
Main Authors: Deepyan Chatterjee, Fiona J. Lewis, Henry J. Sutton, Joe A. Kaczmarski, Xin Gao, Yeping Cai, Hayley A. McNamara, Colin J. Jackson, Ian A. Cockburn
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
immunodominance
B cells
malaria
Plasmodium falciparum
malaria vaccines
circumsporozoite protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003107

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