The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male Rats
Introduction: Oxidative stress plays a key role in the pathophysiology of the Alzheimer's disease and it seems that antioxidants may slow the progress of the disease. The current study aimed at investigating the possible protective effects of callistephin (a natural flavonoid) against amyloid β...
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doaj-eb8dc4be8e2c4d41bbfbbbc96a1505e52020-11-25T02:48:20ZengNegah Institute for Scientific CommunicationAnatomical Sciences Journal2322-36262322-36262017-07-011427378The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male RatsFahimeh Ghasemi Moravej0Siamak Shahidi1Mehdi Mehidzadeh2Sara Soleimani Asl3 Students Research Center, Hamedan University of Medical Sciences, Hamedan, Iran. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Cellular and Molecular Research Center, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Introduction: Oxidative stress plays a key role in the pathophysiology of the Alzheimer's disease and it seems that antioxidants may slow the progress of the disease. The current study aimed at investigating the possible protective effects of callistephin (a natural flavonoid) against amyloid β (Aβ)-induced neurogenesis deficits in rats. Methods: Adult Wistar male rats in the current study were treated with intrahippocampal Aβ as well as intraperitoneal callistephin injection. The day after the last administration, neuroD expression was assessed using an immunohistochemistry method. Finally, data were analyzed with SPSS using the one-way ANOVA test. Results: Results of the current study showed that Aβ significantly decreased the expression of neuroD and callistephin could attenuate these changes. Conclusion: In conclusion, results of the study suggested that callistephin can improve Aβ-induced neurogenesis changes in rats.http://anatomyjournal.ir/article-1-200-en.htmlalzheimer's diseaseneurogenesisanthocyanins |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fahimeh Ghasemi Moravej Siamak Shahidi Mehdi Mehidzadeh Sara Soleimani Asl |
spellingShingle |
Fahimeh Ghasemi Moravej Siamak Shahidi Mehdi Mehidzadeh Sara Soleimani Asl The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male Rats Anatomical Sciences Journal alzheimer's disease neurogenesis anthocyanins |
author_facet |
Fahimeh Ghasemi Moravej Siamak Shahidi Mehdi Mehidzadeh Sara Soleimani Asl |
author_sort |
Fahimeh Ghasemi Moravej |
title |
The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male Rats |
title_short |
The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male Rats |
title_full |
The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male Rats |
title_fullStr |
The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male Rats |
title_full_unstemmed |
The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male Rats |
title_sort |
effect of callistephin on amyloid beta-induced neurotoxicity in the hippocampus of male rats |
publisher |
Negah Institute for Scientific Communication |
series |
Anatomical Sciences Journal |
issn |
2322-3626 2322-3626 |
publishDate |
2017-07-01 |
description |
Introduction: Oxidative stress plays a key role in the pathophysiology of the Alzheimer's disease and it seems that antioxidants may slow the progress of the disease. The current study aimed at investigating the possible protective effects of callistephin (a natural flavonoid) against amyloid β (Aβ)-induced neurogenesis deficits in rats.
Methods: Adult Wistar male rats in the current study were treated with intrahippocampal Aβ as well as intraperitoneal callistephin injection. The day after the last administration, neuroD expression was assessed using an immunohistochemistry method. Finally, data were analyzed with SPSS using the one-way ANOVA test.
Results: Results of the current study showed that Aβ significantly decreased the expression of neuroD and callistephin could attenuate these changes.
Conclusion: In conclusion, results of the study suggested that callistephin can improve Aβ-induced neurogenesis changes in rats. |
topic |
alzheimer's disease neurogenesis anthocyanins |
url |
http://anatomyjournal.ir/article-1-200-en.html |
work_keys_str_mv |
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