Neddylation inactivation represses androgen receptor transcription and inhibits growth, survival and invasion of prostate cancer cells

Neddylation inactivation represses androgen receptor transcription and inhibits growth, survival and invasion of prostate cancer cells

Androgen receptor (AR) and its constitutively active variants (AR-Vs) have been extensively implicated in the progression and recurrence of prostate cancer, making them attractive targets in the treatment of this disease. Whether and how neddylation modification regulates AR, and the therapeutic imp...

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Bibliographic Details
Main Authors: Xiaochen Zhou, Sumin Han, Kari Wilder-Romans, Grace Y. Sun, Hong Zhu, Xiaoqiang Liu, Mingjia Tan, Gongxian Wang, Felix Y. Feng, Yi Sun
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558619303720

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