Mild hypothermia ameliorates anesthesia toxicity in the neonatal macaque brain

Mild hypothermia ameliorates anesthesia toxicity in the neonatal macaque brain

Sedatives and anesthetics can injure the developing brain. They cause apoptosis of neurons and oligodendrocytes, impair synaptic plasticity, inhibit neurogenesis and trigger long-term neurocognitive deficits. The projected vulnerable period in humans extends from the third trimester of pregnancy to...

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Bibliographic Details
Main Authors: Chrysanthy Ikonomidou, George Kirvassilis, Brant S. Swiney, Sophie H. Wang, Jacob N. Huffman, Sasha L. Williams, Kobe Masuoka, Saverio Capuano, III, Kevin R. Brunner, Kristin Crosno, Heather S. Simmons, Andres F. Mejia, Christopher A. Turski, Ansgar Brambrink, Kevin K. Noguchi
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Anesthesia
Brain injury
Apoptosis
Development
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301445

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http://www.sciencedirect.com/science/article/pii/S0969996119301445

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