Predictors of osteoradionecrosis following irradiated tooth extraction
Abstract Background Tooth extraction post radiotherapy is one of the most important risk factors of osteoradionecrosis of the jawbones. The objective of this study was to determine the predictors of osteoradionecrosis (ORN) which were associated with a dental extraction post radiotherapy. Methods A...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-07-01
|
Series: | Radiation Oncology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13014-021-01851-0 |
id |
doaj-ebac24c028d84d94b99a1309dd0b973c |
---|---|
record_format |
Article |
spelling |
doaj-ebac24c028d84d94b99a1309dd0b973c2021-07-18T11:17:20ZengBMCRadiation Oncology1748-717X2021-07-0116111210.1186/s13014-021-01851-0Predictors of osteoradionecrosis following irradiated tooth extractionSzu Ching Khoo0Syed Nabil1Azizah Ahmad Fauzi2Siti Salmiah Mohd Yunus3Wei Cheong Ngeow4Roszalina Ramli5Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universiti Kebangsaan MalaysiaDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universiti Kebangsaan MalaysiaDepartment of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan MalaysiaDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universiti Kebangsaan MalaysiaDepartment of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, University of MalayaDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universiti Kebangsaan MalaysiaAbstract Background Tooth extraction post radiotherapy is one of the most important risk factors of osteoradionecrosis of the jawbones. The objective of this study was to determine the predictors of osteoradionecrosis (ORN) which were associated with a dental extraction post radiotherapy. Methods A retrospective analysis of medical records and dental panoramic tomogram (DPT) of patients with a history of head and neck radiotherapy who underwent dental extraction between August 2005 to October 2019 was conducted. Results Seventy-three patients fulfilled the inclusion criteria. 16 (21.9%) had ORN post dental extraction and 389 teeth were extracted. 33 sockets (8.5%) developed ORN. Univariate analyses showed significant associations with ORN for the following factors: tooth type, tooth pathology, surgical procedure, primary closure, target volume, total dose, timing of extraction post radiotherapy, bony changes at extraction site and visibility of lower and upper cortical line of mandibular canal. Using multivariate analysis, the odds of developing an ORN from a surgical procedure was 6.50 (CI 1.37–30.91, p = 0.02). Dental extraction of more than 5 years after radiotherapy and invisible upper cortical line of mandibular canal on the DPT have the odds of 0.06 (CI 0.01–0.25, p < 0.001) and 9.47 (CI 1.61–55.88, p = 0.01), respectively. Conclusion Extraction more than 5 years after radiotherapy, surgical removal procedure and invisible upper cortical line of mandibular canal on the DPT were the predictors of ORN.https://doi.org/10.1186/s13014-021-01851-0OsteoradionecrosisDental extractionPost radiotherapyPredictors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Szu Ching Khoo Syed Nabil Azizah Ahmad Fauzi Siti Salmiah Mohd Yunus Wei Cheong Ngeow Roszalina Ramli |
spellingShingle |
Szu Ching Khoo Syed Nabil Azizah Ahmad Fauzi Siti Salmiah Mohd Yunus Wei Cheong Ngeow Roszalina Ramli Predictors of osteoradionecrosis following irradiated tooth extraction Radiation Oncology Osteoradionecrosis Dental extraction Post radiotherapy Predictors |
author_facet |
Szu Ching Khoo Syed Nabil Azizah Ahmad Fauzi Siti Salmiah Mohd Yunus Wei Cheong Ngeow Roszalina Ramli |
author_sort |
Szu Ching Khoo |
title |
Predictors of osteoradionecrosis following irradiated tooth extraction |
title_short |
Predictors of osteoradionecrosis following irradiated tooth extraction |
title_full |
Predictors of osteoradionecrosis following irradiated tooth extraction |
title_fullStr |
Predictors of osteoradionecrosis following irradiated tooth extraction |
title_full_unstemmed |
Predictors of osteoradionecrosis following irradiated tooth extraction |
title_sort |
predictors of osteoradionecrosis following irradiated tooth extraction |
publisher |
BMC |
series |
Radiation Oncology |
issn |
1748-717X |
publishDate |
2021-07-01 |
description |
Abstract Background Tooth extraction post radiotherapy is one of the most important risk factors of osteoradionecrosis of the jawbones. The objective of this study was to determine the predictors of osteoradionecrosis (ORN) which were associated with a dental extraction post radiotherapy. Methods A retrospective analysis of medical records and dental panoramic tomogram (DPT) of patients with a history of head and neck radiotherapy who underwent dental extraction between August 2005 to October 2019 was conducted. Results Seventy-three patients fulfilled the inclusion criteria. 16 (21.9%) had ORN post dental extraction and 389 teeth were extracted. 33 sockets (8.5%) developed ORN. Univariate analyses showed significant associations with ORN for the following factors: tooth type, tooth pathology, surgical procedure, primary closure, target volume, total dose, timing of extraction post radiotherapy, bony changes at extraction site and visibility of lower and upper cortical line of mandibular canal. Using multivariate analysis, the odds of developing an ORN from a surgical procedure was 6.50 (CI 1.37–30.91, p = 0.02). Dental extraction of more than 5 years after radiotherapy and invisible upper cortical line of mandibular canal on the DPT have the odds of 0.06 (CI 0.01–0.25, p < 0.001) and 9.47 (CI 1.61–55.88, p = 0.01), respectively. Conclusion Extraction more than 5 years after radiotherapy, surgical removal procedure and invisible upper cortical line of mandibular canal on the DPT were the predictors of ORN. |
topic |
Osteoradionecrosis Dental extraction Post radiotherapy Predictors |
url |
https://doi.org/10.1186/s13014-021-01851-0 |
work_keys_str_mv |
AT szuchingkhoo predictorsofosteoradionecrosisfollowingirradiatedtoothextraction AT syednabil predictorsofosteoradionecrosisfollowingirradiatedtoothextraction AT azizahahmadfauzi predictorsofosteoradionecrosisfollowingirradiatedtoothextraction AT sitisalmiahmohdyunus predictorsofosteoradionecrosisfollowingirradiatedtoothextraction AT weicheongngeow predictorsofosteoradionecrosisfollowingirradiatedtoothextraction AT roszalinaramli predictorsofosteoradionecrosisfollowingirradiatedtoothextraction |
_version_ |
1721296400985096192 |