PGAM5: A crucial role in mitochondrial dynamics and programmed cell death
In response to mitochondrial damage, mitochondria activate mitochondrial dynamics to maintain normal functions, and an imbalance in mitochondrial dynamics triggers multiple programmed cell death processes. Recent studies have shown that phosphoglycerate mutase 5 (PGAM5) is associated with mitochondr...
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doaj-ebb18640b3c34d6095c752cb3aa6a99a2021-04-16T04:48:06ZengElsevierEuropean Journal of Cell Biology0171-93352021-01-011001151144PGAM5: A crucial role in mitochondrial dynamics and programmed cell deathMeiyu Cheng0Nan Lin1Delu Dong2Jiaoyan Ma3Jing Su4Liankun Sun5Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, Jilin, 130021, ChinaKey Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, Jilin, 130021, ChinaKey Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, Jilin, 130021, ChinaKey Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, Jilin, 130021, ChinaCorresponding authors.; Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, Jilin, 130021, ChinaCorresponding authors.; Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, Jilin, 130021, ChinaIn response to mitochondrial damage, mitochondria activate mitochondrial dynamics to maintain normal functions, and an imbalance in mitochondrial dynamics triggers multiple programmed cell death processes. Recent studies have shown that phosphoglycerate mutase 5 (PGAM5) is associated with mitochondrial damage. PGAM5 activates mitochondrial biogenesis and mitophagy to promote a cellular compensatory response when mitochondria are mildly damaged, whereas severe damage to mitochondria leads to PGAM5 inducing excessive mitochondria fission, disruption to mitochondrial movement, and amplification of apoptosis, necroptosis and mitophagic death signals, which eventually evoke cell death. PGAM5 functions mainly through protein-protein interactions and specific Ser/Thr/His protein phosphatase activity. PGAM5 is also regulated by mitochondrial proteases. Detection of PGAM5 and its interacting protein partners should enable a more accurate evaluation of mitochondrial damage and a more precise method for the diagnosis and treatment of diseases.http://www.sciencedirect.com/science/article/pii/S0171933520300832PGAM5Mitochondrial dynamicsApoptosisNecroptosisMitochondrial proteases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meiyu Cheng Nan Lin Delu Dong Jiaoyan Ma Jing Su Liankun Sun |
spellingShingle |
Meiyu Cheng Nan Lin Delu Dong Jiaoyan Ma Jing Su Liankun Sun PGAM5: A crucial role in mitochondrial dynamics and programmed cell death European Journal of Cell Biology PGAM5 Mitochondrial dynamics Apoptosis Necroptosis Mitochondrial proteases |
author_facet |
Meiyu Cheng Nan Lin Delu Dong Jiaoyan Ma Jing Su Liankun Sun |
author_sort |
Meiyu Cheng |
title |
PGAM5: A crucial role in mitochondrial dynamics and programmed cell death |
title_short |
PGAM5: A crucial role in mitochondrial dynamics and programmed cell death |
title_full |
PGAM5: A crucial role in mitochondrial dynamics and programmed cell death |
title_fullStr |
PGAM5: A crucial role in mitochondrial dynamics and programmed cell death |
title_full_unstemmed |
PGAM5: A crucial role in mitochondrial dynamics and programmed cell death |
title_sort |
pgam5: a crucial role in mitochondrial dynamics and programmed cell death |
publisher |
Elsevier |
series |
European Journal of Cell Biology |
issn |
0171-9335 |
publishDate |
2021-01-01 |
description |
In response to mitochondrial damage, mitochondria activate mitochondrial dynamics to maintain normal functions, and an imbalance in mitochondrial dynamics triggers multiple programmed cell death processes. Recent studies have shown that phosphoglycerate mutase 5 (PGAM5) is associated with mitochondrial damage. PGAM5 activates mitochondrial biogenesis and mitophagy to promote a cellular compensatory response when mitochondria are mildly damaged, whereas severe damage to mitochondria leads to PGAM5 inducing excessive mitochondria fission, disruption to mitochondrial movement, and amplification of apoptosis, necroptosis and mitophagic death signals, which eventually evoke cell death. PGAM5 functions mainly through protein-protein interactions and specific Ser/Thr/His protein phosphatase activity. PGAM5 is also regulated by mitochondrial proteases. Detection of PGAM5 and its interacting protein partners should enable a more accurate evaluation of mitochondrial damage and a more precise method for the diagnosis and treatment of diseases. |
topic |
PGAM5 Mitochondrial dynamics Apoptosis Necroptosis Mitochondrial proteases |
url |
http://www.sciencedirect.com/science/article/pii/S0171933520300832 |
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