The Prevalence of Genital Human Papillomavirus Subtypes in a Cohort of Hispanic Women Presenting for Cervical Cancer Screening Along the US-Mexico Border
Introduction : Hispanic women residing along the US-Mexico border have the highest cervical cancer incidence rates in the US. Genital human papillomavirus (HPV) is the major causative agent, but more information is needed about the prevalence and distribution of genital HPV subtypes in this high-ris...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2020-09-01
|
Series: | Cancer Control |
Online Access: | https://doi.org/10.1177/1073274820951780 |
id |
doaj-ebb2d44ce501444893731f373b69c70a |
---|---|
record_format |
Article |
spelling |
doaj-ebb2d44ce501444893731f373b69c70a2020-11-25T03:00:06ZengSAGE PublishingCancer Control1073-27482020-09-012710.1177/1073274820951780The Prevalence of Genital Human Papillomavirus Subtypes in a Cohort of Hispanic Women Presenting for Cervical Cancer Screening Along the US-Mexico BorderNavkiran K. Shokar MA, MD, MPH0Amy Doan BS1Jessica Calderon-Mora MPH, DrPH2Rajkumar Lakshmanaswamy PhD3Subramani Ramadevi PhD4Gurjeet S. Shokar MD5Jennifer Molokwu MD, MPH6Adam Alomari MPH7Alok Dwivedi PhD8 Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA Texas Tech University Health Sciences Center, El Paso, TX, USA Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA Department of Family and Community Medicine, Texas Tech University Health Sciences Center, El Paso,TX, USA Department of Family and Community Medicine, Texas Tech University Health Sciences Center, El Paso,TX, USA Department of Family and Community Medicine, Texas Tech University Health Sciences Center, El Paso,TX, USA Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USAIntroduction : Hispanic women residing along the US-Mexico border have the highest cervical cancer incidence rates in the US. Genital human papillomavirus (HPV) is the major causative agent, but more information is needed about the prevalence and distribution of genital HPV subtypes in this high-risk population. Methods : A population-based cross-sectional study of uninsured Hispanic women along the US-Mexico border was conducted and participants had their cervical specimens undergo DNA extraction followed by HPV genotype testing using the Linear Assay from Roche® Diagnostics, to identify 37 genital HPV subtypes. Results : Among the 585 women aged 21-65 years, 584 self-identfied as Hispanic. Any HPV subtype prevalence was 53.2% (95% CI: 49.0%-57.3%) and of these 52% (i.e. 27.5% of the total) had single infections and 48% (i.e. 25.6% of the total) had multiple infections. High-risk HPV prevalence was 15.6% (95% CI: 24-31.3%). The mean number of subtypes among those testing positive was 2.1 (SD 1.6). The prevalence of any HPV and high-risk HPV showed a U shaped pattern with age; and prevalence of 16/18 and non-16/18 high-risk subtypes (e.g. 31, 33, 35, 39, 45, 51, 52, 58); also varied with age. Forty-one percent of high-risk HPV occurrences were of a subtype not covered by the current nonavalent HPV vaccine. Discussion : Our findings suggest a different high-risk HPV subtype pattern and age distribution among Hispanic women in the USA, which could have implications for future cervical cancer prevention strategies.https://doi.org/10.1177/1073274820951780 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Navkiran K. Shokar MA, MD, MPH Amy Doan BS Jessica Calderon-Mora MPH, DrPH Rajkumar Lakshmanaswamy PhD Subramani Ramadevi PhD Gurjeet S. Shokar MD Jennifer Molokwu MD, MPH Adam Alomari MPH Alok Dwivedi PhD |
spellingShingle |
Navkiran K. Shokar MA, MD, MPH Amy Doan BS Jessica Calderon-Mora MPH, DrPH Rajkumar Lakshmanaswamy PhD Subramani Ramadevi PhD Gurjeet S. Shokar MD Jennifer Molokwu MD, MPH Adam Alomari MPH Alok Dwivedi PhD The Prevalence of Genital Human Papillomavirus Subtypes in a Cohort of Hispanic Women Presenting for Cervical Cancer Screening Along the US-Mexico Border Cancer Control |
author_facet |
Navkiran K. Shokar MA, MD, MPH Amy Doan BS Jessica Calderon-Mora MPH, DrPH Rajkumar Lakshmanaswamy PhD Subramani Ramadevi PhD Gurjeet S. Shokar MD Jennifer Molokwu MD, MPH Adam Alomari MPH Alok Dwivedi PhD |
author_sort |
Navkiran K. Shokar MA, MD, MPH |
title |
The Prevalence of Genital Human Papillomavirus Subtypes in a Cohort of Hispanic Women Presenting for Cervical Cancer Screening Along the US-Mexico Border |
title_short |
The Prevalence of Genital Human Papillomavirus Subtypes in a Cohort of Hispanic Women Presenting for Cervical Cancer Screening Along the US-Mexico Border |
title_full |
The Prevalence of Genital Human Papillomavirus Subtypes in a Cohort of Hispanic Women Presenting for Cervical Cancer Screening Along the US-Mexico Border |
title_fullStr |
The Prevalence of Genital Human Papillomavirus Subtypes in a Cohort of Hispanic Women Presenting for Cervical Cancer Screening Along the US-Mexico Border |
title_full_unstemmed |
The Prevalence of Genital Human Papillomavirus Subtypes in a Cohort of Hispanic Women Presenting for Cervical Cancer Screening Along the US-Mexico Border |
title_sort |
prevalence of genital human papillomavirus subtypes in a cohort of hispanic women presenting for cervical cancer screening along the us-mexico border |
publisher |
SAGE Publishing |
series |
Cancer Control |
issn |
1073-2748 |
publishDate |
2020-09-01 |
description |
Introduction : Hispanic women residing along the US-Mexico border have the highest cervical cancer incidence rates in the US. Genital human papillomavirus (HPV) is the major causative agent, but more information is needed about the prevalence and distribution of genital HPV subtypes in this high-risk population. Methods : A population-based cross-sectional study of uninsured Hispanic women along the US-Mexico border was conducted and participants had their cervical specimens undergo DNA extraction followed by HPV genotype testing using the Linear Assay from Roche® Diagnostics, to identify 37 genital HPV subtypes. Results : Among the 585 women aged 21-65 years, 584 self-identfied as Hispanic. Any HPV subtype prevalence was 53.2% (95% CI: 49.0%-57.3%) and of these 52% (i.e. 27.5% of the total) had single infections and 48% (i.e. 25.6% of the total) had multiple infections. High-risk HPV prevalence was 15.6% (95% CI: 24-31.3%). The mean number of subtypes among those testing positive was 2.1 (SD 1.6). The prevalence of any HPV and high-risk HPV showed a U shaped pattern with age; and prevalence of 16/18 and non-16/18 high-risk subtypes (e.g. 31, 33, 35, 39, 45, 51, 52, 58); also varied with age. Forty-one percent of high-risk HPV occurrences were of a subtype not covered by the current nonavalent HPV vaccine. Discussion : Our findings suggest a different high-risk HPV subtype pattern and age distribution among Hispanic women in the USA, which could have implications for future cervical cancer prevention strategies. |
url |
https://doi.org/10.1177/1073274820951780 |
work_keys_str_mv |
AT navkirankshokarmamdmph theprevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT amydoanbs theprevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT jessicacalderonmoramphdrph theprevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT rajkumarlakshmanaswamyphd theprevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT subramaniramadeviphd theprevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT gurjeetsshokarmd theprevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT jennifermolokwumdmph theprevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT adamalomarimph theprevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT alokdwivediphd theprevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT navkirankshokarmamdmph prevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT amydoanbs prevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT jessicacalderonmoramphdrph prevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT rajkumarlakshmanaswamyphd prevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT subramaniramadeviphd prevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT gurjeetsshokarmd prevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT jennifermolokwumdmph prevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT adamalomarimph prevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder AT alokdwivediphd prevalenceofgenitalhumanpapillomavirussubtypesinacohortofhispanicwomenpresentingforcervicalcancerscreeningalongtheusmexicoborder |
_version_ |
1724699365445992448 |