The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy

The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy

Abstract Background Combination therapy is one of the most effective tools for limiting the emergence of drug resistance in pathogens. Despite the widespread adoption of combination therapy across diseases, drug resistance rates continue to rise, leading to failing treatment regimens. The mechanisms...

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Bibliographic Details
Main Authors: Andrej Trauner, Qingyun Liu, Laura E. Via, Xin Liu, Xianglin Ruan, Lili Liang, Huimin Shi, Ying Chen, Ziling Wang, Ruixia Liang, Wei Zhang, Wang Wei, Jingcai Gao, Gang Sun, Daniela Brites, Kathleen England, Guolong Zhang, Sebastien Gagneux, Clifton E. Barry, Qian Gao
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Genome Biology
Subjects:
Tuberculosis
Within-host evolution
Combination therapy
Drug resistance
Whole genome sequencing
Online Access:http://link.springer.com/article/10.1186/s13059-017-1196-0

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http://link.springer.com/article/10.1186/s13059-017-1196-0

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