In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytoto...

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Main Authors: Stefânia Neiva Lavorato, Policarpo Ademar Sales Júnior, Silvane Maria Fonseca Murta, Alvaro José Romanha, Ricardo José Alves/
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2015-06-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Trypanosoma cruzi
antitrypanosomal agents
Chagas disease
1,3-bisaryloxypropanamines
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000400566&lng=en&tlng=en
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spelling doaj-ebc073d2e53f40df93a1a0921428ba002020-11-25T01:40:25ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.1678-80602015-06-01110456656810.1590/0074-02760150007S0074-02762015000400566In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 culturesStefânia Neiva LavoratoPolicarpo Ademar Sales JúniorSilvane Maria Fonseca MurtaAlvaro José RomanhaRicardo José Alves/We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000400566&lng=en&tlng=enTrypanosoma cruziantitrypanosomal agentsChagas disease1,3-bisaryloxypropanamines
collection DOAJ
language English
format Article
sources DOAJ
author Stefânia Neiva Lavorato
Policarpo Ademar Sales Júnior
Silvane Maria Fonseca Murta
Alvaro José Romanha
Ricardo José Alves/
spellingShingle Stefânia Neiva Lavorato
Policarpo Ademar Sales Júnior
Silvane Maria Fonseca Murta
Alvaro José Romanha
Ricardo José Alves/
In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
Memórias do Instituto Oswaldo Cruz.
Trypanosoma cruzi
antitrypanosomal agents
Chagas disease
1,3-bisaryloxypropanamines
author_facet Stefânia Neiva Lavorato
Policarpo Ademar Sales Júnior
Silvane Maria Fonseca Murta
Alvaro José Romanha
Ricardo José Alves/
author_sort Stefânia Neiva Lavorato
title In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title_short In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title_full In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title_fullStr In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title_full_unstemmed In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title_sort in vitro activity of 1,3-bisaryloxypropanamines against trypanosoma cruzi-infected l929 cultures
publisher Instituto Oswaldo Cruz, Ministério da Saúde
series Memórias do Instituto Oswaldo Cruz.
issn 1678-8060
publishDate 2015-06-01
description We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity.
topic Trypanosoma cruzi
antitrypanosomal agents
Chagas disease
1,3-bisaryloxypropanamines
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000400566&lng=en&tlng=en
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