The acquisition of a temporal task (DRL) by dentate gyrus-selective colchicine lesioned rats / Aquisição de uma tarefa temporal (DRL) por ratos submetidos a lesão seletiva do giro denteado
Previous studies have shown that dentate gyrus damage render rats less efficient than sham-operated controls in the performance of a differential reinforcement of low rates of responding (DRL-20 s) task acquired prior to the lesion; even though the lesioned rats were able to postpone their responses...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SpringerOpen
2006-01-01
|
Series: | Psicologia: Reflexão e Crítica |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-79722006000100021&lng=pt&nrm=iso&tlng=pt |
id |
doaj-ebc65386a1854bb78cc80243a5ab21cf |
---|---|
record_format |
Article |
spelling |
doaj-ebc65386a1854bb78cc80243a5ab21cf2020-11-25T00:06:34ZengSpringerOpenPsicologia: Reflexão e Crítica0102-79721678-71532006-01-01191159165The acquisition of a temporal task (DRL) by dentate gyrus-selective colchicine lesioned rats / Aquisição de uma tarefa temporal (DRL) por ratos submetidos a lesão seletiva do giro denteadoJosé Lino Oliveira BuenoValéria Catelli Infantozzi CostaGilberto Fernando XavierLeno Luis DimaPrevious studies have shown that dentate gyrus damage render rats less efficient than sham-operated controls in the performance of a differential reinforcement of low rates of responding (DRL-20 s) task acquired prior to the lesion; even though the lesioned rats were able to postpone their responses after a previous bar press, they seem to underestimate time relative to sham-operated controls, which interferes with their performance. This study investigated the effects of multiplesite, intradentate, colchicine injections on the acquisition and performance of a DRL-20 s task in rats not exposed to preoperatory training, i.e., trained after the lesion. Results showed that the lesioned rats improved along repetitive training in the DRL-20 s task; however, relative to the sham-operated controls, their acquisition rate was slower and the level of proficiency achieved was poorer, indicating that damage to the dentate gyrus interferes with temporal discrimination.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-79722006000100021&lng=pt&nrm=iso&tlng=ptTemporal discriminationDRL task acquisitionhippocampusdentate gyrus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
José Lino Oliveira Bueno Valéria Catelli Infantozzi Costa Gilberto Fernando Xavier Leno Luis Dima |
spellingShingle |
José Lino Oliveira Bueno Valéria Catelli Infantozzi Costa Gilberto Fernando Xavier Leno Luis Dima The acquisition of a temporal task (DRL) by dentate gyrus-selective colchicine lesioned rats / Aquisição de uma tarefa temporal (DRL) por ratos submetidos a lesão seletiva do giro denteado Psicologia: Reflexão e Crítica Temporal discrimination DRL task acquisition hippocampus dentate gyrus |
author_facet |
José Lino Oliveira Bueno Valéria Catelli Infantozzi Costa Gilberto Fernando Xavier Leno Luis Dima |
author_sort |
José Lino Oliveira Bueno |
title |
The acquisition of a temporal task (DRL) by dentate gyrus-selective colchicine lesioned rats / Aquisição de uma tarefa temporal (DRL) por ratos submetidos a lesão seletiva do giro denteado |
title_short |
The acquisition of a temporal task (DRL) by dentate gyrus-selective colchicine lesioned rats / Aquisição de uma tarefa temporal (DRL) por ratos submetidos a lesão seletiva do giro denteado |
title_full |
The acquisition of a temporal task (DRL) by dentate gyrus-selective colchicine lesioned rats / Aquisição de uma tarefa temporal (DRL) por ratos submetidos a lesão seletiva do giro denteado |
title_fullStr |
The acquisition of a temporal task (DRL) by dentate gyrus-selective colchicine lesioned rats / Aquisição de uma tarefa temporal (DRL) por ratos submetidos a lesão seletiva do giro denteado |
title_full_unstemmed |
The acquisition of a temporal task (DRL) by dentate gyrus-selective colchicine lesioned rats / Aquisição de uma tarefa temporal (DRL) por ratos submetidos a lesão seletiva do giro denteado |
title_sort |
acquisition of a temporal task (drl) by dentate gyrus-selective colchicine lesioned rats / aquisição de uma tarefa temporal (drl) por ratos submetidos a lesão seletiva do giro denteado |
publisher |
SpringerOpen |
series |
Psicologia: Reflexão e Crítica |
issn |
0102-7972 1678-7153 |
publishDate |
2006-01-01 |
description |
Previous studies have shown that dentate gyrus damage render rats less efficient than sham-operated controls in the performance of a differential reinforcement of low rates of responding (DRL-20 s) task acquired prior to the lesion; even though the lesioned rats were able to postpone their responses after a previous bar press, they seem to underestimate time relative to sham-operated controls, which interferes with their performance. This study investigated the effects of multiplesite, intradentate, colchicine injections on the acquisition and performance of a DRL-20 s task in rats not exposed to preoperatory training, i.e., trained after the lesion. Results showed that the lesioned rats improved along repetitive training in the DRL-20 s task; however, relative to the sham-operated controls, their acquisition rate was slower and the level of proficiency achieved was poorer, indicating that damage to the dentate gyrus interferes with temporal discrimination. |
topic |
Temporal discrimination DRL task acquisition hippocampus dentate gyrus |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-79722006000100021&lng=pt&nrm=iso&tlng=pt |
work_keys_str_mv |
AT joselinooliveirabueno theacquisitionofatemporaltaskdrlbydentategyrusselectivecolchicinelesionedratsaquisicaodeumatarefatemporaldrlporratossubmetidosalesaoseletivadogirodenteado AT valeriacatelliinfantozzicosta theacquisitionofatemporaltaskdrlbydentategyrusselectivecolchicinelesionedratsaquisicaodeumatarefatemporaldrlporratossubmetidosalesaoseletivadogirodenteado AT gilbertofernandoxavier theacquisitionofatemporaltaskdrlbydentategyrusselectivecolchicinelesionedratsaquisicaodeumatarefatemporaldrlporratossubmetidosalesaoseletivadogirodenteado AT lenoluisdima theacquisitionofatemporaltaskdrlbydentategyrusselectivecolchicinelesionedratsaquisicaodeumatarefatemporaldrlporratossubmetidosalesaoseletivadogirodenteado AT joselinooliveirabueno acquisitionofatemporaltaskdrlbydentategyrusselectivecolchicinelesionedratsaquisicaodeumatarefatemporaldrlporratossubmetidosalesaoseletivadogirodenteado AT valeriacatelliinfantozzicosta acquisitionofatemporaltaskdrlbydentategyrusselectivecolchicinelesionedratsaquisicaodeumatarefatemporaldrlporratossubmetidosalesaoseletivadogirodenteado AT gilbertofernandoxavier acquisitionofatemporaltaskdrlbydentategyrusselectivecolchicinelesionedratsaquisicaodeumatarefatemporaldrlporratossubmetidosalesaoseletivadogirodenteado AT lenoluisdima acquisitionofatemporaltaskdrlbydentategyrusselectivecolchicinelesionedratsaquisicaodeumatarefatemporaldrlporratossubmetidosalesaoseletivadogirodenteado |
_version_ |
1725421354082107392 |