Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients
The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophil...
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Language: | English |
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Hindawi Limited
2018-01-01
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Series: | Journal of Immunology Research |
Online Access: | http://dx.doi.org/10.1155/2018/2780272 |
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English |
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author |
Chonlaphat Sukasem Chonlawat Chaichan Thapanat Nakkrut Patompong Satapornpong Kanoot Jaruthamsophon Thawinee Jantararoungtong Napatrupron Koomdee Suthida Sririttha Sadeep Medhasi Sarawut Oo-Puthinan Ticha Rerkpattanapipat Jettanong Klaewsongkram Pawinee Rerknimitr Papapit Tuchinda Leena Chularojanamontri Napatra Tovanabutra Apichaya Puangpetch Wichai Aekplakorn |
spellingShingle |
Chonlaphat Sukasem Chonlawat Chaichan Thapanat Nakkrut Patompong Satapornpong Kanoot Jaruthamsophon Thawinee Jantararoungtong Napatrupron Koomdee Suthida Sririttha Sadeep Medhasi Sarawut Oo-Puthinan Ticha Rerkpattanapipat Jettanong Klaewsongkram Pawinee Rerknimitr Papapit Tuchinda Leena Chularojanamontri Napatra Tovanabutra Apichaya Puangpetch Wichai Aekplakorn Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients Journal of Immunology Research |
author_facet |
Chonlaphat Sukasem Chonlawat Chaichan Thapanat Nakkrut Patompong Satapornpong Kanoot Jaruthamsophon Thawinee Jantararoungtong Napatrupron Koomdee Suthida Sririttha Sadeep Medhasi Sarawut Oo-Puthinan Ticha Rerkpattanapipat Jettanong Klaewsongkram Pawinee Rerknimitr Papapit Tuchinda Leena Chularojanamontri Napatra Tovanabutra Apichaya Puangpetch Wichai Aekplakorn |
author_sort |
Chonlaphat Sukasem |
title |
Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients |
title_short |
Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients |
title_full |
Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients |
title_fullStr |
Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients |
title_full_unstemmed |
Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients |
title_sort |
association between hla-b alleles and carbamazepine-induced maculopapular exanthema and severe cutaneous reactions in thai patients |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2018-01-01 |
description |
The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of the present study was to carry out an analysis of the involvement of HLA-B alleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population. A case-control study was performed by genotyping the HLA-B alleles of Thai carbamazepine-induced hypersensitivity reaction patients (17 MPE, 16 SJS/TEN, and 5 DRESS) and 271 carbamazepine-tolerant controls. We also recruited 470 healthy Thai candidate subjects who had not taken carbamazepine. HLA-B∗15:02 showed a significant association with carbamazepine-induced MPE (P=0.0022, odds ratio (OR) (95% confidence interval [CI]) = 7.27 (2.04–25.97)) and carbamazepine-induced SJS/TEN (P=4.46×10−13; OR (95% CI) = 70.91(19.67–255.65)) when compared with carbamazepine-tolerant controls. Carbamazepine-induced SJS/TEN also showed an association with HLA-B∗15:21 allele (P=0.013; OR (95% CI) = 9.54 (1.61–56.57)) when compared with carbamazepine-tolerant controls. HLA-B∗58:01 allele was significantly related to carbamazepine-induced MPE (P=0.007; OR (95% CI) = 4.73 (1.53–14.66)) and DRESS (P=0.0315; OR (95% CI) = 7.55 (1.20–47.58)) when compared with carbamazepine-tolerant controls. These alleles may serve as markers to predict carbamazepine-induced cADRs in the Thai population. |
url |
http://dx.doi.org/10.1155/2018/2780272 |
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doaj-ebce3d514421417ca645fcf275c0d2382020-11-25T01:56:41ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/27802722780272Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai PatientsChonlaphat Sukasem0Chonlawat Chaichan1Thapanat Nakkrut2Patompong Satapornpong3Kanoot Jaruthamsophon4Thawinee Jantararoungtong5Napatrupron Koomdee6Suthida Sririttha7Sadeep Medhasi8Sarawut Oo-Puthinan9Ticha Rerkpattanapipat10Jettanong Klaewsongkram11Pawinee Rerknimitr12Papapit Tuchinda13Leena Chularojanamontri14Napatra Tovanabutra15Apichaya Puangpetch16Wichai Aekplakorn17Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDivision of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDepartment of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, ThailandDivision of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDepartment of Pathology, Faculty of Medicine, Prince of Songkla University, Songkla, ThailandDivision of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDivision of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDivision of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandSchool of Medicine, Mae Fah Luang University, Chiang Rai, ThailandDepartment of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, ThailandThe Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, Bangkok, ThailandThe Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, Bangkok, ThailandThe Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, Bangkok, ThailandThe Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, Bangkok, ThailandThe Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, Bangkok, ThailandThe Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group, Bangkok, ThailandDivision of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDepartment of Community Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandThe HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of the present study was to carry out an analysis of the involvement of HLA-B alleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population. A case-control study was performed by genotyping the HLA-B alleles of Thai carbamazepine-induced hypersensitivity reaction patients (17 MPE, 16 SJS/TEN, and 5 DRESS) and 271 carbamazepine-tolerant controls. We also recruited 470 healthy Thai candidate subjects who had not taken carbamazepine. HLA-B∗15:02 showed a significant association with carbamazepine-induced MPE (P=0.0022, odds ratio (OR) (95% confidence interval [CI]) = 7.27 (2.04–25.97)) and carbamazepine-induced SJS/TEN (P=4.46×10−13; OR (95% CI) = 70.91(19.67–255.65)) when compared with carbamazepine-tolerant controls. Carbamazepine-induced SJS/TEN also showed an association with HLA-B∗15:21 allele (P=0.013; OR (95% CI) = 9.54 (1.61–56.57)) when compared with carbamazepine-tolerant controls. HLA-B∗58:01 allele was significantly related to carbamazepine-induced MPE (P=0.007; OR (95% CI) = 4.73 (1.53–14.66)) and DRESS (P=0.0315; OR (95% CI) = 7.55 (1.20–47.58)) when compared with carbamazepine-tolerant controls. These alleles may serve as markers to predict carbamazepine-induced cADRs in the Thai population.http://dx.doi.org/10.1155/2018/2780272 |