Review of Constituents and Biological Activities of Triterpene Saponins from <i>Glycyrrhizae Radix</i> et Rhizoma and Its Solubilization Characteristics
<i>Glycyrrhizae Radix</i> et Rhizoma is regarded as one of the most popular and commonly used herbal medicines and has been used in traditional Chinese medicine (TCM) prescriptions for over 2000 years. Pentacyclic triterpene saponins are common secondary metabolites in these plants, whic...
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doaj-ebdad262e20e456ea97ea648fd6585b92020-11-25T03:55:12ZengMDPI AGMolecules1420-30492020-08-01253904390410.3390/molecules25173904Review of Constituents and Biological Activities of Triterpene Saponins from <i>Glycyrrhizae Radix</i> et Rhizoma and Its Solubilization CharacteristicsFeifei Li0Bin Liu1Tong Li2Qianwen Wu3Zhiyong Xu4Yuhao Gu5Wen Li6Penglong Wang7Tao Ma8Haimin Lei9School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaCOFCO Nutrition and Health Research Institute, Beijing 102209, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, ChinaSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China<i>Glycyrrhizae Radix</i> et Rhizoma is regarded as one of the most popular and commonly used herbal medicines and has been used in traditional Chinese medicine (TCM) prescriptions for over 2000 years. Pentacyclic triterpene saponins are common secondary metabolites in these plants, which are synthesized via the isoprenoid pathway to produce a hydrophobic triterpenoid aglycone containing a hydrophilic sugar chain. This paper systematically summarizes the chemical structures of triterpene saponins in <i>Glycyrrhizae Radix</i> et Rhizoma and reviews and updates their main biological activities studies. Furthermore, the solubilization characteristics, influences, and mechanisms of <i>Glycyrrhizae Radix</i> et Rhizoma are elaborated. Solubilization of the triterpene saponins from <i>Glycyrrhizae Radix</i> et Rhizoma occurs because they contain the nonpolar sapogenin and water-soluble sidechain. The possible factors affecting the solubilization of <i>Glycyrrhizae Radix</i> et Rhizoma are mainly other crude drugs and the pH of the decoction. Triterpene saponins represented by glycyrrhizin from <i>Glycyrrhizae Radix</i> et Rhizoma characteristically form micelles due to amphiphilicity, which makes solubilization possible. This overview provides guidance regarding a better understanding of <i>Glycyrrhizae</i><i>Radix</i> et Rhizoma and its TCM compatibility, alongside a theoretical basis for the further development and utilization of <i>Glycyrrhizae Radix</i> et Rhizoma.https://www.mdpi.com/1420-3049/25/17/3904<i>Glycyrrhizae Radix</i> et Rhizomatriterpene saponinsglycyrrhizinbiological activitiessolubilization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Feifei Li Bin Liu Tong Li Qianwen Wu Zhiyong Xu Yuhao Gu Wen Li Penglong Wang Tao Ma Haimin Lei |
spellingShingle |
Feifei Li Bin Liu Tong Li Qianwen Wu Zhiyong Xu Yuhao Gu Wen Li Penglong Wang Tao Ma Haimin Lei Review of Constituents and Biological Activities of Triterpene Saponins from <i>Glycyrrhizae Radix</i> et Rhizoma and Its Solubilization Characteristics Molecules <i>Glycyrrhizae Radix</i> et Rhizoma triterpene saponins glycyrrhizin biological activities solubilization |
author_facet |
Feifei Li Bin Liu Tong Li Qianwen Wu Zhiyong Xu Yuhao Gu Wen Li Penglong Wang Tao Ma Haimin Lei |
author_sort |
Feifei Li |
title |
Review of Constituents and Biological Activities of Triterpene Saponins from <i>Glycyrrhizae Radix</i> et Rhizoma and Its Solubilization Characteristics |
title_short |
Review of Constituents and Biological Activities of Triterpene Saponins from <i>Glycyrrhizae Radix</i> et Rhizoma and Its Solubilization Characteristics |
title_full |
Review of Constituents and Biological Activities of Triterpene Saponins from <i>Glycyrrhizae Radix</i> et Rhizoma and Its Solubilization Characteristics |
title_fullStr |
Review of Constituents and Biological Activities of Triterpene Saponins from <i>Glycyrrhizae Radix</i> et Rhizoma and Its Solubilization Characteristics |
title_full_unstemmed |
Review of Constituents and Biological Activities of Triterpene Saponins from <i>Glycyrrhizae Radix</i> et Rhizoma and Its Solubilization Characteristics |
title_sort |
review of constituents and biological activities of triterpene saponins from <i>glycyrrhizae radix</i> et rhizoma and its solubilization characteristics |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-08-01 |
description |
<i>Glycyrrhizae Radix</i> et Rhizoma is regarded as one of the most popular and commonly used herbal medicines and has been used in traditional Chinese medicine (TCM) prescriptions for over 2000 years. Pentacyclic triterpene saponins are common secondary metabolites in these plants, which are synthesized via the isoprenoid pathway to produce a hydrophobic triterpenoid aglycone containing a hydrophilic sugar chain. This paper systematically summarizes the chemical structures of triterpene saponins in <i>Glycyrrhizae Radix</i> et Rhizoma and reviews and updates their main biological activities studies. Furthermore, the solubilization characteristics, influences, and mechanisms of <i>Glycyrrhizae Radix</i> et Rhizoma are elaborated. Solubilization of the triterpene saponins from <i>Glycyrrhizae Radix</i> et Rhizoma occurs because they contain the nonpolar sapogenin and water-soluble sidechain. The possible factors affecting the solubilization of <i>Glycyrrhizae Radix</i> et Rhizoma are mainly other crude drugs and the pH of the decoction. Triterpene saponins represented by glycyrrhizin from <i>Glycyrrhizae Radix</i> et Rhizoma characteristically form micelles due to amphiphilicity, which makes solubilization possible. This overview provides guidance regarding a better understanding of <i>Glycyrrhizae</i><i>Radix</i> et Rhizoma and its TCM compatibility, alongside a theoretical basis for the further development and utilization of <i>Glycyrrhizae Radix</i> et Rhizoma. |
topic |
<i>Glycyrrhizae Radix</i> et Rhizoma triterpene saponins glycyrrhizin biological activities solubilization |
url |
https://www.mdpi.com/1420-3049/25/17/3904 |
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