Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A<sub>2</sub>-IIA in microvascular endothelial cells of the injured brain

Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A<sub>2</sub>-IIA in microvascular endothelial cells of the injured brain

<p>Abstract</p> <p>Background</p> <p>Secreted phospholipase A<sub>2</sub>-IIA (sPLA<sub>2</sub>-IIA) is an inducible enzyme released under several inflammatory conditions. It has been shown that sPLA<sub>2</sub>-IIA is released from r...

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Bibliographic Details
Main Authors: Wang Guansong, Qian Pin, Xu Zhi, Zhang Jiqiang, Wang Yaoli, Cheng Saiyu, Cai Wenqin, Qian Guisheng, Wang Changzheng, DeCoster Mark A
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Journal of Neuroinflammation
Subjects:
Secreted phospholipase A<sub>2</sub>-IIA
Brain microvascular endothelial cells
Permeability
Lipopolysaccharide
Nitric oxide
Inducible NO synthase
JAK3
STAT1
Online Access:http://www.jneuroinflammation.com/content/9/1/170

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http://www.jneuroinflammation.com/content/9/1/170

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