Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

Bryostatin 1 is a unique therapeutic lead, however its scarce natural sources have hampered its use in treatment of human disease. Here, the authors use a scalable synthesis of bryostatin 1 to make close-in analogs which potently induce increased cell surface expression holding potential for immunot...

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Main Authors:	Clayton Hardman, Stephen Ho, Akira Shimizu, Quang Luu-Nguyen, Jack L. Sloane, Mohamed S. A. Soliman, Matthew D. Marsden, Jerome A. Zack, Paul A. Wender
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15742-7

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spelling	doaj-ebe37911de374c93a36c1ee604f378a02021-05-11T08:14:18ZengNature Publishing GroupNature Communications2041-17232020-04-0111111110.1038/s41467-020-15742-7Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapyClayton Hardman0Stephen Ho1Akira Shimizu2Quang Luu-Nguyen3Jack L. Sloane4Mohamed S. A. Soliman5Matthew D. Marsden6Jerome A. Zack7Paul A. Wender8Departments of Chemistry and of Chemical and Systems Biology, Stanford UniversityDepartments of Chemistry and of Chemical and Systems Biology, Stanford UniversityDepartments of Chemistry and of Chemical and Systems Biology, Stanford UniversityDepartments of Chemistry and of Chemical and Systems Biology, Stanford UniversityDepartments of Chemistry and of Chemical and Systems Biology, Stanford UniversityDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los AngelesDivision of Hematology and Oncology, Department of Medicine, University of California, Los AngelesDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los AngelesDepartments of Chemistry and of Chemical and Systems Biology, Stanford UniversityBryostatin 1 is a unique therapeutic lead, however its scarce natural sources have hampered its use in treatment of human disease. Here, the authors use a scalable synthesis of bryostatin 1 to make close-in analogs which potently induce increased cell surface expression holding potential for immunotherapy.https://doi.org/10.1038/s41467-020-15742-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Clayton Hardman Stephen Ho Akira Shimizu Quang Luu-Nguyen Jack L. Sloane Mohamed S. A. Soliman Matthew D. Marsden Jerome A. Zack Paul A. Wender
spellingShingle	Clayton Hardman Stephen Ho Akira Shimizu Quang Luu-Nguyen Jack L. Sloane Mohamed S. A. Soliman Matthew D. Marsden Jerome A. Zack Paul A. Wender Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy Nature Communications
author_facet	Clayton Hardman Stephen Ho Akira Shimizu Quang Luu-Nguyen Jack L. Sloane Mohamed S. A. Soliman Matthew D. Marsden Jerome A. Zack Paul A. Wender
author_sort	Clayton Hardman
title	Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
title_short	Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
title_full	Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
title_fullStr	Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
title_full_unstemmed	Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
title_sort	synthesis and evaluation of designed pkc modulators for enhanced cancer immunotherapy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-04-01
description	Bryostatin 1 is a unique therapeutic lead, however its scarce natural sources have hampered its use in treatment of human disease. Here, the authors use a scalable synthesis of bryostatin 1 to make close-in analogs which potently induce increased cell surface expression holding potential for immunotherapy.
url	https://doi.org/10.1038/s41467-020-15742-7
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Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

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