Phase modulation of insulin pulses enhances glucose regulation and enables inter-islet synchronization.

Insulin is secreted in a pulsatile manner from multiple micro-organs called the islets of Langerhans. The amplitude and phase (shape) of insulin secretion are modulated by numerous factors including glucose. The role of phase modulation in glucose homeostasis is not well understood compared to the o...

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Bibliographic Details
Main Authors: Boah Lee, Taegeun Song, Kayoung Lee, Jaeyoon Kim, Seungmin Han, Per-Olof Berggren, Sung Ho Ryu, Junghyo Jo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5325581?pdf=render