C/EBPα Induces Highly Efficient Macrophage Transdifferentiation of B Lymphoma and Leukemia Cell Lines and Impairs Their Tumorigenicity
Earlier work demonstrated that the transcription factor C/EBPα can convert immature and mature murine B lineage cells into functional macrophages. Testing >20 human lymphoma and leukemia B cell lines, we found that most can be transdifferentiated at least partially into macrophage-like cells, pr...
Main Authors: | Francesca Rapino, Eloy F. Robles, Jose A. Richter-Larrea, Eric M. Kallin, Jose A. Martinez-Climent, Thomas Graf |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2013-04-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124713001101 |
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