Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease

Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease

Cardiovascular diseases (CVD) remain the major cause of death and premature disability in Western societies. Assessing the risk of CVD is an important aspect in clinical decision-making. Among the growing number of molecules that are studied for their potential utility as CVD biomarkers, a lot of at...

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Main Authors: Stella Bernardi, Fleur Bossi, Barbara Toffoli, Bruno Fabris
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2016/1752854
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spelling doaj-ebf0dde2c1434464893d547e405af3d52020-11-24T22:37:23ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/17528541752854Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular DiseaseStella Bernardi0Fleur Bossi1Barbara Toffoli2Bruno Fabris3Department of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume, 34149 Trieste, ItalyDepartment of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume, 34149 Trieste, ItalyDepartment of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume, 34149 Trieste, ItalyDepartment of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume, 34149 Trieste, ItalyCardiovascular diseases (CVD) remain the major cause of death and premature disability in Western societies. Assessing the risk of CVD is an important aspect in clinical decision-making. Among the growing number of molecules that are studied for their potential utility as CVD biomarkers, a lot of attention has been focused on osteoprotegerin (OPG) and its ligands, which are receptor activator of nuclear factor κB ligand (RANKL) and TNF-related apoptosis-inducing ligand. Based on the existing literature and on our experience in this field, here we review what the possible roles of OPG and TRAIL in CVD are and their potential utility as CVD biomarkers.http://dx.doi.org/10.1155/2016/1752854
collection DOAJ
language English
format Article
sources DOAJ
author Stella Bernardi
Fleur Bossi
Barbara Toffoli
Bruno Fabris
spellingShingle Stella Bernardi
Fleur Bossi
Barbara Toffoli
Bruno Fabris
Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
BioMed Research International
author_facet Stella Bernardi
Fleur Bossi
Barbara Toffoli
Bruno Fabris
author_sort Stella Bernardi
title Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title_short Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title_full Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title_fullStr Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title_full_unstemmed Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title_sort roles and clinical applications of opg and trail as biomarkers in cardiovascular disease
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2016-01-01
description Cardiovascular diseases (CVD) remain the major cause of death and premature disability in Western societies. Assessing the risk of CVD is an important aspect in clinical decision-making. Among the growing number of molecules that are studied for their potential utility as CVD biomarkers, a lot of attention has been focused on osteoprotegerin (OPG) and its ligands, which are receptor activator of nuclear factor κB ligand (RANKL) and TNF-related apoptosis-inducing ligand. Based on the existing literature and on our experience in this field, here we review what the possible roles of OPG and TRAIL in CVD are and their potential utility as CVD biomarkers.
url http://dx.doi.org/10.1155/2016/1752854
work_keys_str_mv AT stellabernardi rolesandclinicalapplicationsofopgandtrailasbiomarkersincardiovasculardisease
AT fleurbossi rolesandclinicalapplicationsofopgandtrailasbiomarkersincardiovasculardisease
AT barbaratoffoli rolesandclinicalapplicationsofopgandtrailasbiomarkersincardiovasculardisease
AT brunofabris rolesandclinicalapplicationsofopgandtrailasbiomarkersincardiovasculardisease
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