Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study.
AIM: To study the pattern and prevalence of dyslipidemia in a large representative sample of four selected regions in India. METHODS: Phase I of the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study was conducted in a representative population of three states of India [Tamil Nadu...
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doaj-ebf3835c9f57458b8be6e8a5925a935c2020-11-25T01:56:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9680810.1371/journal.pone.0096808Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study.Shashank R JoshiRanjit Mohan AnjanaMohan DeepaRajendra PradeepaAnil BhansaliVinay K DhandaniaPrashant P JoshiRanjit UnnikrishnanElangovan NirmalRadhakrishnan SubashiniSri Venkata MadhuPaturi Vishnupriya RaoAshok Kumar DasTanvir KaurDeepak Kumar ShuklaViswanathan MohanICMR-INDIAB Collaborative Study GroupAIM: To study the pattern and prevalence of dyslipidemia in a large representative sample of four selected regions in India. METHODS: Phase I of the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study was conducted in a representative population of three states of India [Tamil Nadu, Maharashtra and Jharkhand] and one Union Territory [Chandigarh], and covered a population of 213 million people using stratified multistage sampling design to recruit individuals ≥20 years of age. All the study subjects (n = 16,607) underwent anthropometric measurements and oral glucose tolerance tests were done using capillary blood (except in self-reported diabetes). In addition, in every 5th subject (n = 2042), a fasting venous sample was collected and assayed for lipids. Dyslipidemia was diagnosed using National Cholesterol Education Programme (NCEP) guidelines. RESULTS: Of the subjects studied, 13.9% had hypercholesterolemia, 29.5% had hypertriglyceridemia, 72.3% had low HDL-C, 11.8% had high LDL-C levels and 79% had abnormalities in one of the lipid parameters. Regional disparity exists with the highest rates of hypercholesterolemia observed in Tamilnadu (18.3%), highest rates of hypertriglyceridemia in Chandigarh (38.6%), highest rates of low HDL-C in Jharkhand (76.8%) and highest rates of high LDL-C in Tamilnadu (15.8%). Except for low HDL-C and in the state of Maharashtra, in all other states, urban residents had the highest prevalence of lipid abnormalities compared to rural residents. Low HDL-C was the most common lipid abnormality (72.3%) in all the four regions studied; in 44.9% of subjects, it was present as an isolated abnormality. Common significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia. CONCLUSION: The prevalence of dyslipidemia is very high in India, which calls for urgent lifestyle intervention strategies to prevent and manage this important cardiovascular risk factor.http://europepmc.org/articles/PMC4016101?pdf=render |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shashank R Joshi Ranjit Mohan Anjana Mohan Deepa Rajendra Pradeepa Anil Bhansali Vinay K Dhandania Prashant P Joshi Ranjit Unnikrishnan Elangovan Nirmal Radhakrishnan Subashini Sri Venkata Madhu Paturi Vishnupriya Rao Ashok Kumar Das Tanvir Kaur Deepak Kumar Shukla Viswanathan Mohan ICMR-INDIAB Collaborative Study Group |
spellingShingle |
Shashank R Joshi Ranjit Mohan Anjana Mohan Deepa Rajendra Pradeepa Anil Bhansali Vinay K Dhandania Prashant P Joshi Ranjit Unnikrishnan Elangovan Nirmal Radhakrishnan Subashini Sri Venkata Madhu Paturi Vishnupriya Rao Ashok Kumar Das Tanvir Kaur Deepak Kumar Shukla Viswanathan Mohan ICMR-INDIAB Collaborative Study Group Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study. PLoS ONE |
author_facet |
Shashank R Joshi Ranjit Mohan Anjana Mohan Deepa Rajendra Pradeepa Anil Bhansali Vinay K Dhandania Prashant P Joshi Ranjit Unnikrishnan Elangovan Nirmal Radhakrishnan Subashini Sri Venkata Madhu Paturi Vishnupriya Rao Ashok Kumar Das Tanvir Kaur Deepak Kumar Shukla Viswanathan Mohan ICMR-INDIAB Collaborative Study Group |
author_sort |
Shashank R Joshi |
title |
Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study. |
title_short |
Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study. |
title_full |
Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study. |
title_fullStr |
Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study. |
title_full_unstemmed |
Prevalence of dyslipidemia in urban and rural India: the ICMR-INDIAB study. |
title_sort |
prevalence of dyslipidemia in urban and rural india: the icmr-indiab study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
AIM: To study the pattern and prevalence of dyslipidemia in a large representative sample of four selected regions in India. METHODS: Phase I of the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study was conducted in a representative population of three states of India [Tamil Nadu, Maharashtra and Jharkhand] and one Union Territory [Chandigarh], and covered a population of 213 million people using stratified multistage sampling design to recruit individuals ≥20 years of age. All the study subjects (n = 16,607) underwent anthropometric measurements and oral glucose tolerance tests were done using capillary blood (except in self-reported diabetes). In addition, in every 5th subject (n = 2042), a fasting venous sample was collected and assayed for lipids. Dyslipidemia was diagnosed using National Cholesterol Education Programme (NCEP) guidelines. RESULTS: Of the subjects studied, 13.9% had hypercholesterolemia, 29.5% had hypertriglyceridemia, 72.3% had low HDL-C, 11.8% had high LDL-C levels and 79% had abnormalities in one of the lipid parameters. Regional disparity exists with the highest rates of hypercholesterolemia observed in Tamilnadu (18.3%), highest rates of hypertriglyceridemia in Chandigarh (38.6%), highest rates of low HDL-C in Jharkhand (76.8%) and highest rates of high LDL-C in Tamilnadu (15.8%). Except for low HDL-C and in the state of Maharashtra, in all other states, urban residents had the highest prevalence of lipid abnormalities compared to rural residents. Low HDL-C was the most common lipid abnormality (72.3%) in all the four regions studied; in 44.9% of subjects, it was present as an isolated abnormality. Common significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia. CONCLUSION: The prevalence of dyslipidemia is very high in India, which calls for urgent lifestyle intervention strategies to prevent and manage this important cardiovascular risk factor. |
url |
http://europepmc.org/articles/PMC4016101?pdf=render |
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