Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study
Atmospheric air pollution has been associated with a range of adverse health effects. The environment plays a causative role in the development of Systemic Sclerosis (SSc). The aim of the present study is to explore the association between particulate (PM10) and benzene (B) exposure in Italian patie...
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doaj-ebf544e961a9457692089f87d291100c2020-11-24T21:53:29ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012017-10-011411129710.3390/ijerph14111297ijerph14111297Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation StudyAlice Borghini0Andrea Poscia1Silvia Bosello2Adele Anna Teleman3Mario Bocci4Lanfranco Iodice5Gianfranco Ferraccioli6Daniele Ignazio La Milìa7Umberto Moscato8Institute of Public Health-Hygiene Section, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyInstitute of Public Health-Hygiene Section, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyDepartment of Rheumatology, Fondazione Policlinico Gemelli, 00168 Rome, ItalyInstitute of Public Health-Hygiene Section, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyDepartment of Rheumatology, Fondazione Policlinico Gemelli, 00168 Rome, ItalyVice Medical Director, San Raffaele Cassino Hospital, 03043 Cassino (FR), ItalyDepartment of Rheumatology, Fondazione Policlinico Gemelli, 00168 Rome, ItalyInstitute of Public Health-Hygiene Section, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyInstitute of Public Health-Hygiene Section, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyAtmospheric air pollution has been associated with a range of adverse health effects. The environment plays a causative role in the development of Systemic Sclerosis (SSc). The aim of the present study is to explore the association between particulate (PM10) and benzene (B) exposure in Italian patients with systemic sclerosis and their clinical characteristics of the disease. A correlation study was conducted by enrolling 88 patients who suffer from SSc at the Fondazione Policlinico “A. Gemelli” in Rome (Italy) in the period from January 2013 to January 2014. The average mean concentrations of B (in 11 monitoring sites) and PM10 (in 14 sites) were calculated using data from the Regional Environmental Protection Agency’s monitoring stations located throughout the Lazio region (Italy) and then correlated with the clinical characteristics of the SSc patients. Of the study sample, 92.5% were female. The mean age was 55 ± 12.9 years old and the mean disease duration from the onset of Raynaud’s phenomenon was 13.0 ± 9.4 years. The Spearman’s correlation showed that concentrations of B correlate directly with the skin score (R = 0.3; p ≤ 0.05) and inversely with Diffusing Lung Carbon Monoxide (DLCO) results (R = −0.36; p = 0.04). This study suggests a possible role of B in the development of diffuse skin disease and in a worse progression of the lung manifestations of SSc.https://www.mdpi.com/1660-4601/14/11/1297systemic sclerosisbenzeneparticulate matter (PM10)environmental exposure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alice Borghini Andrea Poscia Silvia Bosello Adele Anna Teleman Mario Bocci Lanfranco Iodice Gianfranco Ferraccioli Daniele Ignazio La Milìa Umberto Moscato |
spellingShingle |
Alice Borghini Andrea Poscia Silvia Bosello Adele Anna Teleman Mario Bocci Lanfranco Iodice Gianfranco Ferraccioli Daniele Ignazio La Milìa Umberto Moscato Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study International Journal of Environmental Research and Public Health systemic sclerosis benzene particulate matter (PM10) environmental exposure |
author_facet |
Alice Borghini Andrea Poscia Silvia Bosello Adele Anna Teleman Mario Bocci Lanfranco Iodice Gianfranco Ferraccioli Daniele Ignazio La Milìa Umberto Moscato |
author_sort |
Alice Borghini |
title |
Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study |
title_short |
Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study |
title_full |
Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study |
title_fullStr |
Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study |
title_full_unstemmed |
Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study |
title_sort |
environmental pollution by benzene and pm10 and clinical manifestations of systemic sclerosis: a correlation study |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2017-10-01 |
description |
Atmospheric air pollution has been associated with a range of adverse health effects. The environment plays a causative role in the development of Systemic Sclerosis (SSc). The aim of the present study is to explore the association between particulate (PM10) and benzene (B) exposure in Italian patients with systemic sclerosis and their clinical characteristics of the disease. A correlation study was conducted by enrolling 88 patients who suffer from SSc at the Fondazione Policlinico “A. Gemelli” in Rome (Italy) in the period from January 2013 to January 2014. The average mean concentrations of B (in 11 monitoring sites) and PM10 (in 14 sites) were calculated using data from the Regional Environmental Protection Agency’s monitoring stations located throughout the Lazio region (Italy) and then correlated with the clinical characteristics of the SSc patients. Of the study sample, 92.5% were female. The mean age was 55 ± 12.9 years old and the mean disease duration from the onset of Raynaud’s phenomenon was 13.0 ± 9.4 years. The Spearman’s correlation showed that concentrations of B correlate directly with the skin score (R = 0.3; p ≤ 0.05) and inversely with Diffusing Lung Carbon Monoxide (DLCO) results (R = −0.36; p = 0.04). This study suggests a possible role of B in the development of diffuse skin disease and in a worse progression of the lung manifestations of SSc. |
topic |
systemic sclerosis benzene particulate matter (PM10) environmental exposure |
url |
https://www.mdpi.com/1660-4601/14/11/1297 |
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