Regulation of TGF-β1-induced proapoptotic signaling by growth factor receptors and extracellular matrix receptor integrins in the liver

Regulation of TGF-β1-induced proapoptotic signaling by growth factor receptors and extracellular matrix receptor integrins in the liver

Hepatocellular carcinoma (HCC) often arises from chronically diseased livers. Persistent liver inflammation causes the accumulation of excessive extracellular matrix (ECM) proteins and impairs the liver function, finally leading to the development of HCC. A pleiotropic cytokine, transforming growth...

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Bibliographic Details
Main Authors: Iwata eOzaki, Hiroshi eHamajima, Sachiko eMatsuhashi, Toshihiko eMizuta
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-10-01
Series:Frontiers in Physiology
Subjects:
integrin
Hepatocellular Carcinoma
liver fibrosis
Smad
TGF-β
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00078/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00078/full

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