Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial
OBJECTIVES: Prevention and reduction of pain, anxiety, and fear during medical procedures is one of the most important factors that should be considered in pediatric emergencies. The aim of this study was to compare the efficacy of oral versus intranasal midazolam in sedation during radiologic imagi...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2020-01-01
|
Series: | Turkish Journal of Emergency Medicine |
Subjects: | |
Online Access: | http://www.turkjemergmed.org/article.asp?issn=2452-2473;year=2020;volume=20;issue=4;spage=168;epage=174;aulast=Mayel |
id |
doaj-ebf7e1bb4cd64f749f7930c271f11d83 |
---|---|
record_format |
Article |
spelling |
doaj-ebf7e1bb4cd64f749f7930c271f11d832021-02-03T07:14:45ZengWolters Kluwer Medknow PublicationsTurkish Journal of Emergency Medicine2452-24732452-24732020-01-0120416817410.4103/2452-2473.297461Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trialMasoud MayelMehdi Ahmadi NejadMehdi Sadeghi KhabazMaliheh Sadat BazrafshaniEhsan MohajeriOBJECTIVES: Prevention and reduction of pain, anxiety, and fear during medical procedures is one of the most important factors that should be considered in pediatric emergencies. The aim of this study was to compare the efficacy of oral versus intranasal midazolam in sedation during radiologic imaging in the largest province of Iran, Kerman. MATERIALS AND METHODS: Eighty children were enrolled in this single-blind clinical trial based on convenience sampling and were divided into two groups receiving 0.5 mg/kg midazolam in oral route administration and 0.2 mg/kg midazolam in intranasal route administration. Finally, 75 patients remained for evaluating medication acceptability, sedation level, onset time of sedation, additional sedative dose, adverse effects of sedation, and provider satisfaction. RESULTS: Children in the intranasal group accepted medication more easily (89.8% vs. 36.9%; P≤ 0.001), while these children received a lower sedation dose, but the sedation level in both methods was similar (P = 0.72). Our findings showed that children in the intranasal sedation group had a faster onset of sedation compared to the oral group (17.94 ± 8.99 vs. 34.50 ± 11.45; P≤ 0.001). The frequency of midazolam side effects had no difference between the groups (29.7% vs. 15.8%; P = 0.15). CONCLUSION: Intranasal midazolam with a lower sedation dose induces a faster onset and better acceptance. Intranasal midazolam can be used as an effective sedative method for pediatric patients, especially in emergency wards.http://www.turkjemergmed.org/article.asp?issn=2452-2473;year=2020;volume=20;issue=4;spage=168;epage=174;aulast=Mayelemergency wardintranasalmidazolamradiologic imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masoud Mayel Mehdi Ahmadi Nejad Mehdi Sadeghi Khabaz Maliheh Sadat Bazrafshani Ehsan Mohajeri |
spellingShingle |
Masoud Mayel Mehdi Ahmadi Nejad Mehdi Sadeghi Khabaz Maliheh Sadat Bazrafshani Ehsan Mohajeri Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial Turkish Journal of Emergency Medicine emergency ward intranasal midazolam radiologic imaging |
author_facet |
Masoud Mayel Mehdi Ahmadi Nejad Mehdi Sadeghi Khabaz Maliheh Sadat Bazrafshani Ehsan Mohajeri |
author_sort |
Masoud Mayel |
title |
Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial |
title_short |
Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial |
title_full |
Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial |
title_fullStr |
Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial |
title_full_unstemmed |
Intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: A single-blind randomized trial |
title_sort |
intranasal midazolam sedation as an effective sedation route in pediatric patients for radiologic imaging in the emergency ward: a single-blind randomized trial |
publisher |
Wolters Kluwer Medknow Publications |
series |
Turkish Journal of Emergency Medicine |
issn |
2452-2473 2452-2473 |
publishDate |
2020-01-01 |
description |
OBJECTIVES: Prevention and reduction of pain, anxiety, and fear during medical procedures is one of the most important factors that should be considered in pediatric emergencies. The aim of this study was to compare the efficacy of oral versus intranasal midazolam in sedation during radiologic imaging in the largest province of Iran, Kerman.
MATERIALS AND METHODS: Eighty children were enrolled in this single-blind clinical trial based on convenience sampling and were divided into two groups receiving 0.5 mg/kg midazolam in oral route administration and 0.2 mg/kg midazolam in intranasal route administration. Finally, 75 patients remained for evaluating medication acceptability, sedation level, onset time of sedation, additional sedative dose, adverse effects of sedation, and provider satisfaction.
RESULTS: Children in the intranasal group accepted medication more easily (89.8% vs. 36.9%; P≤ 0.001), while these children received a lower sedation dose, but the sedation level in both methods was similar (P = 0.72). Our findings showed that children in the intranasal sedation group had a faster onset of sedation compared to the oral group (17.94 ± 8.99 vs. 34.50 ± 11.45; P≤ 0.001). The frequency of midazolam side effects had no difference between the groups (29.7% vs. 15.8%; P = 0.15).
CONCLUSION: Intranasal midazolam with a lower sedation dose induces a faster onset and better acceptance. Intranasal midazolam can be used as an effective sedative method for pediatric patients, especially in emergency wards. |
topic |
emergency ward intranasal midazolam radiologic imaging |
url |
http://www.turkjemergmed.org/article.asp?issn=2452-2473;year=2020;volume=20;issue=4;spage=168;epage=174;aulast=Mayel |
work_keys_str_mv |
AT masoudmayel intranasalmidazolamsedationasaneffectivesedationrouteinpediatricpatientsforradiologicimagingintheemergencywardasingleblindrandomizedtrial AT mehdiahmadinejad intranasalmidazolamsedationasaneffectivesedationrouteinpediatricpatientsforradiologicimagingintheemergencywardasingleblindrandomizedtrial AT mehdisadeghikhabaz intranasalmidazolamsedationasaneffectivesedationrouteinpediatricpatientsforradiologicimagingintheemergencywardasingleblindrandomizedtrial AT malihehsadatbazrafshani intranasalmidazolamsedationasaneffectivesedationrouteinpediatricpatientsforradiologicimagingintheemergencywardasingleblindrandomizedtrial AT ehsanmohajeri intranasalmidazolamsedationasaneffectivesedationrouteinpediatricpatientsforradiologicimagingintheemergencywardasingleblindrandomizedtrial |
_version_ |
1724288272745627648 |