KL1333, a derivative of β-lapachone, protects against cisplatin-induced ototoxicity in mouse cochlear cultures

KL1333, a derivative of β-lapachone, protects against cisplatin-induced ototoxicity in mouse cochlear cultures

Cisplatin (CP) is a chemotherapeutic drug used to treat cancerous solid tumors, but it causes serious side effects, including ototoxicity. The major cause of CP-induced ototoxicity is increased levels of mitochondrial reactive oxygen species (ROS). In this study, we examined the effect of 2-Isopropy...

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Bibliographic Details
Main Authors: Han-Sol Lee, Ye-Ri Kim, In-Kyu Lee, Un-Kyung Kim, Jeong-In Baek, Kyu-Yup Lee
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cochlear explant
Cisplatin
KL1333
ROS
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220302596

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http://www.sciencedirect.com/science/article/pii/S0753332220302596

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