Oligodendrocyte-Specific Deletion of <i>FGFR1</i> Reduces Cerebellar Inflammation and Neurodegeneration in MOG<sub>35-55</sub>-Induced EAE

Oligodendrocyte-Specific Deletion of <i>FGFR1</i> Reduces Cerebellar Inflammation and Neurodegeneration in MOG<sub>35-55</sub>-Induced EAE

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system (CNS). MS commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs significantly contribute to clinical disability, and symptoms such as tremor, ataxia, and dysarthria...

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Bibliographic Details
Main Authors: Ranjithkumar Rajendran, Vinothkumar Rajendran, Mario Giraldo-Velasquez, Fevronia-Foivi Megalofonou, Fynn Gurski, Christine Stadelmann, Srikanth Karnati, Martin Berghoff
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
FGFR1
oligodendrocytes
demyelination
inflammation
cerebellum
EAE
Online Access:https://www.mdpi.com/1422-0067/22/17/9495

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