INTESTINAL MICROBIOTA MUTUALISM AND GASTROINTESTINAL DISEASES
The purpose of this work is to investigate the link between an altered intestinal mcrobiota or dysbiosis and chronic inflammatory disorders, in particular inflammatory bowel disease (IBD). Along with probiotics, faecal microbiota transplantation (FMT) opts to be a promising therapeutic treatment...
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| Format: | Article |
| Language: | English |
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Associazione Italiana Giovani Medici
2015-04-01
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| Series: | Euromediterranean Biomedical Journal |
| Online Access: | http://www.embj.org/images/ISSUE_2015/tomasello_1.pdf |
| Summary: | The purpose of this work is to investigate the link between an altered intestinal mcrobiota
or dysbiosis and chronic inflammatory disorders, in particular inflammatory bowel
disease (IBD). Along with probiotics, faecal microbiota transplantation (FMT) opts to be
a promising therapeutic treatment for restoring the bacterial homeostasis of the human
intestine and reducing the risk of colorectal carcinogenesis. Microbiota is the complex
microbial flora that resides in the gut establishing a mutually beneficial relationship.
Alteration of the microbiota’s composition, termed as dysbiosis, may lead to
pathological conditions. Treatment with probiotics can restore the normal commensal
flora in IBD. Intestinal microbiota affects the circadian rhythm which in turn regulates
the expression of different genes in GALT (gut associated lymphoid tissue) playing a
role in the prevention of inflammation and colorectal cancer (CRC) progression. This
article highlights the involvement of different microbial strains in the pathogenesis of
dysbiosis and in the creation of a carcinogenic milieu caused by an altered stimulation
of the immune system. Therapies targeting the equilibrium of the microbiota to switch
off chronic inflammation and prevent the progression to CRC seem to be a promising
therapeutic tool for a variety of inflammation-associated diseases. |
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| ISSN: | 2279-7165 2279-7165 |