Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation
<p><span><strong>Background:</strong></span> Holmes tremor (HT) is an irregular, low-frequency rest tremor associated with prominent action and postural tremors. Currently, the most effective stereotactic target and neurophysiologic characterization of HT, spec...
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doaj-ec185634822043dfb2409a8f2b1cc1572021-04-02T14:07:40ZengUbiquity PressTremor and Other Hyperkinetic Movements2160-82882016-06-01610.7916/D8S182JJ270Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain StimulationAdolfo Ramirez-Zamora0Brian C. Kaszuba1Lucy Gee2Julia Prusik3Fabio Danisi4Damian Shin5Julie G. Pilitsis6Albany Medical CenterAlbany Medical CollegeAlbany Medical CollegeAlbany Medical CenterKingston Neurological AssociatesAlbany Medical CollegeAlbany Medical College Albany Medical Center<p><span><strong>Background:</strong></span> Holmes tremor (HT) is an irregular, low-frequency rest tremor associated with prominent action and postural tremors. Currently, the most effective stereotactic target and neurophysiologic characterization of HT, specifically local field potentials (LFPs) are uncertain. We present the outcome, intraoperative neurophysiologic analysis with characterization of LFPs in a patient managed with left globus pallidus interna deep brain stimulation (Gpi DBS).</p><p><span><strong>Case Report:</strong></span> A 24-year-old male underwent left Gpi DBS for medically refractory HT. LFPs demonstrated highest powers in the delta range in Gpi. At the 6-month follow-up, a 90% reduction in tremor was observed.</p><p><span><strong>Discussion:</strong></span> Pallidal DBS should be considered as an alternative target for management of refractory HT. LFP demonstrated neuronal activity associated with higher power in the delta region, similarly seen in patients with generalized dystonia.</p><p> </p>https://tremorjournal.org/index.php/tremor/article/view/388 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adolfo Ramirez-Zamora Brian C. Kaszuba Lucy Gee Julia Prusik Fabio Danisi Damian Shin Julie G. Pilitsis |
spellingShingle |
Adolfo Ramirez-Zamora Brian C. Kaszuba Lucy Gee Julia Prusik Fabio Danisi Damian Shin Julie G. Pilitsis Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation Tremor and Other Hyperkinetic Movements |
author_facet |
Adolfo Ramirez-Zamora Brian C. Kaszuba Lucy Gee Julia Prusik Fabio Danisi Damian Shin Julie G. Pilitsis |
author_sort |
Adolfo Ramirez-Zamora |
title |
Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation |
title_short |
Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation |
title_full |
Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation |
title_fullStr |
Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation |
title_full_unstemmed |
Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation |
title_sort |
clinical outcome and characterization of local field potentials in holmes tremor treated with pallidal deep brain stimulation |
publisher |
Ubiquity Press |
series |
Tremor and Other Hyperkinetic Movements |
issn |
2160-8288 |
publishDate |
2016-06-01 |
description |
<p><span><strong>Background:</strong></span> Holmes tremor (HT) is an irregular, low-frequency rest tremor associated with prominent action and postural tremors. Currently, the most effective stereotactic target and neurophysiologic characterization of HT, specifically local field potentials (LFPs) are uncertain. We present the outcome, intraoperative neurophysiologic analysis with characterization of LFPs in a patient managed with left globus pallidus interna deep brain stimulation (Gpi DBS).</p><p><span><strong>Case Report:</strong></span> A 24-year-old male underwent left Gpi DBS for medically refractory HT. LFPs demonstrated highest powers in the delta range in Gpi. At the 6-month follow-up, a 90% reduction in tremor was observed.</p><p><span><strong>Discussion:</strong></span> Pallidal DBS should be considered as an alternative target for management of refractory HT. LFP demonstrated neuronal activity associated with higher power in the delta region, similarly seen in patients with generalized dystonia.</p><p> </p> |
url |
https://tremorjournal.org/index.php/tremor/article/view/388 |
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