Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer

Colorectal cancer (CRC) represents the third most common type of cancer in developed countries and one of the leading causes of cancer deaths worldwide. Personalized management of CRC has gained increasing attention since there are large inter-individual variations in the prognosis and response to d...

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Main Authors:	Cong-Min Zhang, Jin-Feng Lv, Liang Gong, Lin-Yu Yu, Xiao-Ping Chen, Hong-Hao Zhou, Lan Fan
Format:	Article
Language:	English
Published:	MDPI AG 2016-09-01
Series:	International Journal of Environmental Research and Public Health
Subjects:	colorectal cancer personalized treatment mismatch repair system microsatellite instability adjuvant chemotherapy targeted therapy immune checkpoint inhibitor therapy
Online Access:	http://www.mdpi.com/1660-4601/13/9/892

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spelling	doaj-ec21315b60844fa0a36177adac33884a2020-11-25T01:02:16ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012016-09-0113989210.3390/ijerph13090892ijerph13090892Role of Deficient Mismatch Repair in the Personalized Management of Colorectal CancerCong-Min Zhang0Jin-Feng Lv1Liang Gong2Lin-Yu Yu3Xiao-Ping Chen4Hong-Hao Zhou5Lan Fan6Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaColorectal cancer (CRC) represents the third most common type of cancer in developed countries and one of the leading causes of cancer deaths worldwide. Personalized management of CRC has gained increasing attention since there are large inter-individual variations in the prognosis and response to drugs used to treat CRC owing to molecular heterogeneity. Approximately 15% of CRCs are caused by deficient mismatch repair (dMMR) characterized by microsatellite instability (MSI) phenotype. The present review is aimed at highlighting the role of MMR status in informing prognosis and personalized treatment of CRC including adjuvant chemotherapy, targeted therapy, and immune checkpoint inhibitor therapy to guide the individualized therapy of CRC.http://www.mdpi.com/1660-4601/13/9/892colorectal cancerpersonalized treatmentmismatch repair systemmicrosatellite instabilityadjuvant chemotherapytargeted therapyimmune checkpoint inhibitor therapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Cong-Min Zhang Jin-Feng Lv Liang Gong Lin-Yu Yu Xiao-Ping Chen Hong-Hao Zhou Lan Fan
spellingShingle	Cong-Min Zhang Jin-Feng Lv Liang Gong Lin-Yu Yu Xiao-Ping Chen Hong-Hao Zhou Lan Fan Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer International Journal of Environmental Research and Public Health colorectal cancer personalized treatment mismatch repair system microsatellite instability adjuvant chemotherapy targeted therapy immune checkpoint inhibitor therapy
author_facet	Cong-Min Zhang Jin-Feng Lv Liang Gong Lin-Yu Yu Xiao-Ping Chen Hong-Hao Zhou Lan Fan
author_sort	Cong-Min Zhang
title	Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer
title_short	Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer
title_full	Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer
title_fullStr	Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer
title_full_unstemmed	Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer
title_sort	role of deficient mismatch repair in the personalized management of colorectal cancer
publisher	MDPI AG
series	International Journal of Environmental Research and Public Health
issn	1660-4601
publishDate	2016-09-01
description	Colorectal cancer (CRC) represents the third most common type of cancer in developed countries and one of the leading causes of cancer deaths worldwide. Personalized management of CRC has gained increasing attention since there are large inter-individual variations in the prognosis and response to drugs used to treat CRC owing to molecular heterogeneity. Approximately 15% of CRCs are caused by deficient mismatch repair (dMMR) characterized by microsatellite instability (MSI) phenotype. The present review is aimed at highlighting the role of MMR status in informing prognosis and personalized treatment of CRC including adjuvant chemotherapy, targeted therapy, and immune checkpoint inhibitor therapy to guide the individualized therapy of CRC.
topic	colorectal cancer personalized treatment mismatch repair system microsatellite instability adjuvant chemotherapy targeted therapy immune checkpoint inhibitor therapy
url	http://www.mdpi.com/1660-4601/13/9/892
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Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer

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