Comparison of automated and manual protocols for magnetic resonance imaging assessment of liver iron concentration
Abstract Objective: To compare automated and manual magnetic resonance imaging protocols for estimating liver iron concentrations at 1.5 T. Materials and Methods: Magnetic resonance imaging examination of the liver was performed in 53 patients with clinically suspected hepatic iron overload and in...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
|
Series: | Radiologia Brasileira |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842020000300005&lng=en&tlng=en |
id |
doaj-ec2ffb90a6f9414497e875a205b317f8 |
---|---|
record_format |
Article |
spelling |
doaj-ec2ffb90a6f9414497e875a205b317f82020-11-25T03:28:51ZengColégio Brasileiro de Radiologia e Diagnóstico por ImagemRadiologia Brasileira0100-39841678-709953314815410.1590/0100-3984.2019.0029S0100-39842020000300005Comparison of automated and manual protocols for magnetic resonance imaging assessment of liver iron concentrationIzabella de Campos Carvalho LopesManuel SchützeMarina Borges BolinaTarcísio Ângelo de Oliveira SobrinhoLaura Filgueiras Mourão RamosRenata Lopes Furletti Caldeira DinizJuliano de Lara FernandesMaria Helena Albernaz SiqueiraAbstract Objective: To compare automated and manual magnetic resonance imaging protocols for estimating liver iron concentrations at 1.5 T. Materials and Methods: Magnetic resonance imaging examination of the liver was performed in 53 patients with clinically suspected hepatic iron overload and in 21 control subjects. Liver iron concentrations were then estimated by two examiners who were blinded to the groups. The examiners employed automated T2* and T1 mapping, as well as manual T2* and signal-intensity-ratio method. We analyzed accuracy by using ROC curves. Interobserver and intraobserver agreement were analyzed by calculating two-way intraclass correlation coefficients. Results: The area under the ROC curve (to discriminate between patients and controls) was 0.912 for automated T2* mapping, 0.934 for the signal-intensity-ratio method, 0.908 for manual T2*, and 0.80 for T1 mapping, the last method differing significantly from the other three. The level of interobserver and intraobserver agreement was good (intraclass correlation coefficient, 0.938-0.998; p < 0.05). Correlations involving T1 mapping, although still significant, were lower. Conclusion: At 1.5 T, T2* mapping is a rapid tool that shows promise for the diagnosis of liver iron overload, whereas T1 mapping shows less accuracy. The performance of T1 mapping is poorer than is that of T2* methods.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842020000300005&lng=en&tlng=enfígado/diagnóstico por imagemfígado/metabolismosobrecarga de ferro/diagnóstico por imagemferro/metabolismoressonância magnética/métodosprocessamento de imagem assistida por computador/métodos |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Izabella de Campos Carvalho Lopes Manuel Schütze Marina Borges Bolina Tarcísio Ângelo de Oliveira Sobrinho Laura Filgueiras Mourão Ramos Renata Lopes Furletti Caldeira Diniz Juliano de Lara Fernandes Maria Helena Albernaz Siqueira |
spellingShingle |
Izabella de Campos Carvalho Lopes Manuel Schütze Marina Borges Bolina Tarcísio Ângelo de Oliveira Sobrinho Laura Filgueiras Mourão Ramos Renata Lopes Furletti Caldeira Diniz Juliano de Lara Fernandes Maria Helena Albernaz Siqueira Comparison of automated and manual protocols for magnetic resonance imaging assessment of liver iron concentration Radiologia Brasileira fígado/diagnóstico por imagem fígado/metabolismo sobrecarga de ferro/diagnóstico por imagem ferro/metabolismo ressonância magnética/métodos processamento de imagem assistida por computador/métodos |
author_facet |
Izabella de Campos Carvalho Lopes Manuel Schütze Marina Borges Bolina Tarcísio Ângelo de Oliveira Sobrinho Laura Filgueiras Mourão Ramos Renata Lopes Furletti Caldeira Diniz Juliano de Lara Fernandes Maria Helena Albernaz Siqueira |
author_sort |
Izabella de Campos Carvalho Lopes |
title |
Comparison of automated and manual protocols for magnetic resonance imaging assessment of liver iron concentration |
title_short |
Comparison of automated and manual protocols for magnetic resonance imaging assessment of liver iron concentration |
title_full |
Comparison of automated and manual protocols for magnetic resonance imaging assessment of liver iron concentration |
title_fullStr |
Comparison of automated and manual protocols for magnetic resonance imaging assessment of liver iron concentration |
title_full_unstemmed |
Comparison of automated and manual protocols for magnetic resonance imaging assessment of liver iron concentration |
title_sort |
comparison of automated and manual protocols for magnetic resonance imaging assessment of liver iron concentration |
publisher |
Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
series |
Radiologia Brasileira |
issn |
0100-3984 1678-7099 |
description |
Abstract Objective: To compare automated and manual magnetic resonance imaging protocols for estimating liver iron concentrations at 1.5 T. Materials and Methods: Magnetic resonance imaging examination of the liver was performed in 53 patients with clinically suspected hepatic iron overload and in 21 control subjects. Liver iron concentrations were then estimated by two examiners who were blinded to the groups. The examiners employed automated T2* and T1 mapping, as well as manual T2* and signal-intensity-ratio method. We analyzed accuracy by using ROC curves. Interobserver and intraobserver agreement were analyzed by calculating two-way intraclass correlation coefficients. Results: The area under the ROC curve (to discriminate between patients and controls) was 0.912 for automated T2* mapping, 0.934 for the signal-intensity-ratio method, 0.908 for manual T2*, and 0.80 for T1 mapping, the last method differing significantly from the other three. The level of interobserver and intraobserver agreement was good (intraclass correlation coefficient, 0.938-0.998; p < 0.05). Correlations involving T1 mapping, although still significant, were lower. Conclusion: At 1.5 T, T2* mapping is a rapid tool that shows promise for the diagnosis of liver iron overload, whereas T1 mapping shows less accuracy. The performance of T1 mapping is poorer than is that of T2* methods. |
topic |
fígado/diagnóstico por imagem fígado/metabolismo sobrecarga de ferro/diagnóstico por imagem ferro/metabolismo ressonância magnética/métodos processamento de imagem assistida por computador/métodos |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842020000300005&lng=en&tlng=en |
work_keys_str_mv |
AT izabelladecamposcarvalholopes comparisonofautomatedandmanualprotocolsformagneticresonanceimagingassessmentofliverironconcentration AT manuelschutze comparisonofautomatedandmanualprotocolsformagneticresonanceimagingassessmentofliverironconcentration AT marinaborgesbolina comparisonofautomatedandmanualprotocolsformagneticresonanceimagingassessmentofliverironconcentration AT tarcisioangelodeoliveirasobrinho comparisonofautomatedandmanualprotocolsformagneticresonanceimagingassessmentofliverironconcentration AT laurafilgueirasmouraoramos comparisonofautomatedandmanualprotocolsformagneticresonanceimagingassessmentofliverironconcentration AT renatalopesfurletticaldeiradiniz comparisonofautomatedandmanualprotocolsformagneticresonanceimagingassessmentofliverironconcentration AT julianodelarafernandes comparisonofautomatedandmanualprotocolsformagneticresonanceimagingassessmentofliverironconcentration AT mariahelenaalbernazsiqueira comparisonofautomatedandmanualprotocolsformagneticresonanceimagingassessmentofliverironconcentration |
_version_ |
1724582405976621056 |