Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections
Abstract Background The aim of this study was to investigate whether marketed antibiotics package sizes are in accordance with treatment durations recommended in guidelines for prescribing antibiotics in sore throat and urinary tract infections. Methods National drug database was searched with limit...
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doaj-ec335e48454f4c41a5db1c4db0cf138f2020-11-25T02:56:53ZengBMCAntimicrobial Resistance and Infection Control2047-29942019-02-018111210.1186/s13756-019-0495-5Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infectionsDoris Rusic0Josko Bozic1Josipa Bukic2Ana Seselja Perisin3Dario Leskur4Darko Modun5Sinisa Tomic6Department of Pharmacy, University of Split School of MedicineDepartment of Pathophysiology, University of Split School of MedicineDepartment of Pharmacy, University of Split School of MedicineDepartment of Pharmacy, University of Split School of MedicineDepartment of Pharmacy, University of Split School of MedicineDepartment of Pharmacy, University of Split School of MedicineDepartment of Pharmacy, University of Split School of MedicineAbstract Background The aim of this study was to investigate whether marketed antibiotics package sizes are in accordance with treatment durations recommended in guidelines for prescribing antibiotics in sore throat and urinary tract infections. Methods National drug database was searched with limitation to Antibacterials for systemic use. Formulations which did not have pre-specified dosage unit by the manufacturer were excluded (e.g. powders for oral solutions). The final list contained 94 drugs with 23 different active substances. This list was then cross-referenced with selected antimicrobial prescribing guidelines provided by Intersectoral Society for Antibiotic Resistance Control (ISKRA), National Institute for Health and Care Excellence (NICE) and The Infectious Diseases Society of America (IDSA). Results Seven packages matched ISKRA guidelines on sore throat while 16 were mismatched. Considering drug packages under reimbursement, 3 matched ISKRA guidelines and 8 were mismatched. Only 3 packages matched IDSA guidelines for comparable indications, and 18 were mismatched. When considering NICE guidelines there were 5 mismatched and only one package that was in accordance with the guidelines. ISKRA guidelines for urinary tract infections matched 23 packages and mismatched 58 packages. IDSA guidelines for urinary tract infections matched one package and were mismatched in 15 cases. Conclusions One of the causes of leftover antibiotics is poor accordance of antibiotic package size with treatment recommendation duration. This should be identified as a potential target for reduction of excess antibiotics in the community. Measures that promote patient adherence to therapy and patient education should be considered essential to manage proper handling of leftover antibiotics.http://link.springer.com/article/10.1186/s13756-019-0495-5Antibiotic resistancePrescribing guidelineSore throatUrinary tract infections |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Doris Rusic Josko Bozic Josipa Bukic Ana Seselja Perisin Dario Leskur Darko Modun Sinisa Tomic |
spellingShingle |
Doris Rusic Josko Bozic Josipa Bukic Ana Seselja Perisin Dario Leskur Darko Modun Sinisa Tomic Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections Antimicrobial Resistance and Infection Control Antibiotic resistance Prescribing guideline Sore throat Urinary tract infections |
author_facet |
Doris Rusic Josko Bozic Josipa Bukic Ana Seselja Perisin Dario Leskur Darko Modun Sinisa Tomic |
author_sort |
Doris Rusic |
title |
Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections |
title_short |
Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections |
title_full |
Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections |
title_fullStr |
Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections |
title_full_unstemmed |
Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections |
title_sort |
evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections |
publisher |
BMC |
series |
Antimicrobial Resistance and Infection Control |
issn |
2047-2994 |
publishDate |
2019-02-01 |
description |
Abstract Background The aim of this study was to investigate whether marketed antibiotics package sizes are in accordance with treatment durations recommended in guidelines for prescribing antibiotics in sore throat and urinary tract infections. Methods National drug database was searched with limitation to Antibacterials for systemic use. Formulations which did not have pre-specified dosage unit by the manufacturer were excluded (e.g. powders for oral solutions). The final list contained 94 drugs with 23 different active substances. This list was then cross-referenced with selected antimicrobial prescribing guidelines provided by Intersectoral Society for Antibiotic Resistance Control (ISKRA), National Institute for Health and Care Excellence (NICE) and The Infectious Diseases Society of America (IDSA). Results Seven packages matched ISKRA guidelines on sore throat while 16 were mismatched. Considering drug packages under reimbursement, 3 matched ISKRA guidelines and 8 were mismatched. Only 3 packages matched IDSA guidelines for comparable indications, and 18 were mismatched. When considering NICE guidelines there were 5 mismatched and only one package that was in accordance with the guidelines. ISKRA guidelines for urinary tract infections matched 23 packages and mismatched 58 packages. IDSA guidelines for urinary tract infections matched one package and were mismatched in 15 cases. Conclusions One of the causes of leftover antibiotics is poor accordance of antibiotic package size with treatment recommendation duration. This should be identified as a potential target for reduction of excess antibiotics in the community. Measures that promote patient adherence to therapy and patient education should be considered essential to manage proper handling of leftover antibiotics. |
topic |
Antibiotic resistance Prescribing guideline Sore throat Urinary tract infections |
url |
http://link.springer.com/article/10.1186/s13756-019-0495-5 |
work_keys_str_mv |
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