Suitability of α1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort study
Abstract Background Online hemodiafiltration (OL-HDF), whether in pre-dilution OL-HDF (pre-HDF) or post-dilution OL-HDF (post-HDF), is conducted to efficiently remove low molecular weight proteins from the blood of patients requiring dialysis. β2-microglobulin (β2-MG) and α1-microglobulin (α1-MG) ar...
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doaj-ec33e9c3ebe1489ba084e6dd38fc769d2021-02-21T12:47:48ZengBMCRenal Replacement Therapy2059-13812021-02-01711610.1186/s41100-021-00326-ySuitability of α1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort studyKenji Sakurai0Hiromi Hosoya1Yoshitaka Kurihara2Takeshi Saito3Hashimoto ClinicHashimoto ClinicHashimoto ClinicHashimoto ClinicAbstract Background Online hemodiafiltration (OL-HDF), whether in pre-dilution OL-HDF (pre-HDF) or post-dilution OL-HDF (post-HDF), is conducted to efficiently remove low molecular weight proteins from the blood of patients requiring dialysis. β2-microglobulin (β2-MG) and α1-microglobulin (α1-MG) are used as biomarkers to evaluate removal efficiency of OL-HDF. We aimed to evaluate the relationship between β2-MG and α1-MG reduction rates and the amount of albumin leakage. Furthermore, we statistically analyzed the relationship between the α1-MG reduction rate and α1-MG removal amount, and its suitability as a biomarker for evaluating the removal efficiency of OL-HDF. Methods We collected the results of regularly conducted routine evaluations to assess the efficiency of OL-HDF from cases of patients undergoing maintenance dialysis at our clinic from 2018 to 2019. Data on was collected on both pre-HDF and post-HDF sessions. β2-MG and α1-MG reduction rates were analyzed. Regression analysis on reduction rates showed a significant correlation between the α1-MG reduction rate and the α1-MG removal amount. Results We conducted 435 tests on OL-HDF efficiency in 87 cases undergoing maintenance dialysis at our clinic in 2018 and 2019. There were 80.7 ± 4.5% for the β2-MG reduction rate, 33.8 ± 9.4% for the α1-MG reduction rate, and 3.9 ± 1.8 g/s for the amount of albumin leakage. There was no correlation between the β2-MG reduction rate and the α1-MG reduction rate, or between the amount of albumin leakage and β2-MG reduction rate. Conclusion α1-MG reduction rate was found to correlate with its removal amount, demonstrating its suitability as a biomarker for evaluating the removal efficiency of OL-HDF. Trial registration Retrospectively registered.https://doi.org/10.1186/s41100-021-00326-yα1-microglobulinReduction rate of α1-microglobulinOnline hemodiafiltrationBiomarker for evaluation of removal efficiency |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kenji Sakurai Hiromi Hosoya Yoshitaka Kurihara Takeshi Saito |
spellingShingle |
Kenji Sakurai Hiromi Hosoya Yoshitaka Kurihara Takeshi Saito Suitability of α1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort study Renal Replacement Therapy α1-microglobulin Reduction rate of α1-microglobulin Online hemodiafiltration Biomarker for evaluation of removal efficiency |
author_facet |
Kenji Sakurai Hiromi Hosoya Yoshitaka Kurihara Takeshi Saito |
author_sort |
Kenji Sakurai |
title |
Suitability of α1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort study |
title_short |
Suitability of α1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort study |
title_full |
Suitability of α1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort study |
title_fullStr |
Suitability of α1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort study |
title_full_unstemmed |
Suitability of α1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort study |
title_sort |
suitability of α1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort study |
publisher |
BMC |
series |
Renal Replacement Therapy |
issn |
2059-1381 |
publishDate |
2021-02-01 |
description |
Abstract Background Online hemodiafiltration (OL-HDF), whether in pre-dilution OL-HDF (pre-HDF) or post-dilution OL-HDF (post-HDF), is conducted to efficiently remove low molecular weight proteins from the blood of patients requiring dialysis. β2-microglobulin (β2-MG) and α1-microglobulin (α1-MG) are used as biomarkers to evaluate removal efficiency of OL-HDF. We aimed to evaluate the relationship between β2-MG and α1-MG reduction rates and the amount of albumin leakage. Furthermore, we statistically analyzed the relationship between the α1-MG reduction rate and α1-MG removal amount, and its suitability as a biomarker for evaluating the removal efficiency of OL-HDF. Methods We collected the results of regularly conducted routine evaluations to assess the efficiency of OL-HDF from cases of patients undergoing maintenance dialysis at our clinic from 2018 to 2019. Data on was collected on both pre-HDF and post-HDF sessions. β2-MG and α1-MG reduction rates were analyzed. Regression analysis on reduction rates showed a significant correlation between the α1-MG reduction rate and the α1-MG removal amount. Results We conducted 435 tests on OL-HDF efficiency in 87 cases undergoing maintenance dialysis at our clinic in 2018 and 2019. There were 80.7 ± 4.5% for the β2-MG reduction rate, 33.8 ± 9.4% for the α1-MG reduction rate, and 3.9 ± 1.8 g/s for the amount of albumin leakage. There was no correlation between the β2-MG reduction rate and the α1-MG reduction rate, or between the amount of albumin leakage and β2-MG reduction rate. Conclusion α1-MG reduction rate was found to correlate with its removal amount, demonstrating its suitability as a biomarker for evaluating the removal efficiency of OL-HDF. Trial registration Retrospectively registered. |
topic |
α1-microglobulin Reduction rate of α1-microglobulin Online hemodiafiltration Biomarker for evaluation of removal efficiency |
url |
https://doi.org/10.1186/s41100-021-00326-y |
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