Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease

Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease

There are nearly 50 million people with Alzheimer's disease (AD) worldwide and currently no disease modifying treatment is available. AD is characterized by deposits of Amyloid-β (Aβ), neurofibrillary tangles, and neuroinflammation, and several drug discovery programmes studies have focussed on...

Full description

Bibliographic Details
Main Authors:	Isabelle L. Sumner, Ross A. Edwards, Ayodeji A. Asuni, Jessica L. Teeling
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-04-01
Series:	Frontiers in Neuroscience
Subjects:	amyloid antibody engineering immunotherapy Alzheimers disease neuroinflammation
Online Access:	http://journal.frontiersin.org/article/10.3389/fnins.2018.00254/full

Similar Items

Application of Antibody Fragments Against Aβ With Emphasis on Combined Application With Nanoparticles in Alzheimer’s Disease
by: Zhi-Ting Sun, et al.
Published: (2021-04-01)

Alzheimer’s disease and immunotherapy: what is wrong with clinical trials?
by: Kohyama K, et al.
Published: (2015-01-01)

NEW ROLES FOR FC RECEPTORS IN NEURODEGENERATION-THE IMPACT ON IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE
by: James P. Fuller, et al.
Published: (2014-08-01)

Immunotherapy for the treatment of Alzheimer's disease: amyloid-β or tau, which is the right target?
by: Castillo-Carranza DL, et al.
Published: (2013-12-01)

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease
by: Tobias Gustavsson, et al.
Published: (2020-09-01)

An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease
by: Anna Lord, et al.
Published: (2009-12-01)

The presubiculum is preserved from neurodegenerative changes in Alzheimer’s disease
by: Christina E. Murray, et al.
Published: (2018-07-01)

BETA AMYLOID POLYCLONAL ANTIBODY IMMUNOGENICITY AS EARLY DEVELOPMENT STUDY OF EARLY DIAGNOSIS FOR ALZHEIMER’S DISEASE
by: M. Rasjad Indra, et al.
Published: (2017-01-01)

The role of astrocytes in amyloid production and Alzheimer's disease
by: Georgia R. Frost, et al.
Published: (2017-01-01)

Pharmacotherapy of Alzheimer’s Disease: Seeking Clarity in a Time of Uncertainty
by: Nurul Husna Ibrahim, et al.
Published: (2020-03-01)

Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review
by: Tien-Wei Yu, et al.
Published: (2021-07-01)

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition
by: Brittani R. Price, et al.
Published: (2020-08-01)

The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study
by: Rola Ismail, et al.
Published: (2020-05-01)

Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study
by: Diana K. Franco-Bocanegra, et al.
Published: (2019-11-01)

Brain injury, neuroinflammation and Alzheimer’s disease
by: Joshua eBreunig, et al.
Published: (2013-07-01)

ANIMAL Antidépresseurs, neuroinflammation et maladie d'alzheimer
by: Gosselin, Thomas
Published: (2016)

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease
by: David J. Braun, et al.
Published: (2020-09-01)

Alternative Targets to Fight Alzheimer’s Disease: Focus on Astrocytes
by: Marta Valenza, et al.
Published: (2021-04-01)

Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease
by: Zein Al-Atrache, et al.
Published: (2019-02-01)

The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease
by: Bingyuan Ji, et al.
Published: (2019-10-01)

Doxycycline for Alzheimer’s Disease: Fighting β-Amyloid Oligomers and Neuroinflammation
by: Claudia Balducci, et al.
Published: (2019-07-01)

Hypothyroïdie et processus neurodégénératifs associés à la maladie d’Alzheimer
by: Chaalal, Amina
Published: (2014)

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
by: Justyna Sosna, et al.
Published: (2018-03-01)

CB2 cannabinoid receptor as potential target against Alzheimer’s disease
by: Ester eAso, et al.
Published: (2016-05-01)

Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease
by: M. Coma, et al.
Published: (2010-06-01)

A Preliminary Study of Cu Exposure Effects upon Alzheimer’s Amyloid Pathology
by: Alexander Pilozzi, et al.
Published: (2020-03-01)

Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease
by: Yinyin Tan, et al.
Published: (2021-04-01)

Neuroprotective Effects of Chronic Resveratrol Treatment and Exercise Training in the 3xTg-AD Mouse Model of Alzheimer’s Disease
by: Tom L. Broderick, et al.
Published: (2020-10-01)

PET Imaging of Neuroinflammation in Alzheimer’s Disease
by: Rong Zhou, et al.
Published: (2021-09-01)

Emerging Immunotherapies for Parkinson Disease
by: Samis M. A. Zella, et al.
Published: (2018-12-01)

Imaging Alzheimer's disease pathophysiology with PET
by: Lucas Porcello Schilling, et al.

Advances in Genetic and Molecular Understanding of Alzheimer’s Disease
by: Laura Ibanez, et al.
Published: (2021-08-01)

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta
by: Vitaly Vasilevko, et al.
Published: (2010-09-01)

Melatonin in Alzheimer’s Disease
by: Jian-Zhi Wang, et al.
Published: (2013-07-01)

Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease
by: Jacob M. Basak, et al.
Published: (2021-05-01)

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice
by: Yan Liu, et al.
Published: (2020-01-01)

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy
by: Kevin A. Clayton, et al.
Published: (2017-12-01)

Prévention du phénomène de nucléation et de la propagation des tauopathies par immunothérapie passive utilisant un anticorps ciblant une région centrale de la protéine tau
by: Albert, Marie
Published: (2018)

Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer’s Disease
by: Leela Paladugu, et al.
Published: (2021-01-01)

In vivo detection of amyloid plaques by gadolinium-stained MRI can be used to demonstrate the efficacy of an anti-amyloid immunotherapy
by: Mathieu D. Santin, et al.
Published: (2016-03-01)

Cannot write session to /tmp/vufind_sessions/sess_n5mr5s0mktmu9adsrm6vg22ivo