Repurposing colchicine’s journey in view of drug-to-drug interactions. A review
Colchicine’s medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular...
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doaj-ec389cb247754429b46a449ce4de33632021-07-13T04:09:42ZengElsevierToxicology Reports2214-75002021-01-01813891393Repurposing colchicine’s journey in view of drug-to-drug interactions. A reviewDimitrios A. Vrachatis0Konstantinos A. Papathanasiou1Sotiria G. Giotaki2Konstantinos E. Iliodromitis3Theodore G. Papaioannou4Giulio G. Stefanini5Michael Cleman6Gerasimos Siasos7Bernhard Reimers8Alexandra Lansky9Jean-Claude Tardif10Spyridon G. Deftereos11George Giannopoulos122nd Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece2nd Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece2nd Department of Cardiology, National and Kapodistrian University of Athens, Athens, GreeceEvangelisches Krankenhaus Hagen-Haspe, Clinic for Cardiology and Electrophysiology, GermanyFirst Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Greece; Department of History of Medicine and Medical Ethics, Medical School, National and Kapodistrian University of Athens, GreeceDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Humanitas Research Hospital IRCCS, Rozzano, Milan, ItalySection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA3rd Department of Cardiology, “Sotiria Hospital”, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Humanitas Research Hospital IRCCS, Rozzano, Milan, ItalySection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USAMontreal Heart Institute Montreal, University of Montreal, Montreal, Canada2nd Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece; Corresponding author at: 2nd Department of Cardiology, Attikon Hospital, National and Kapodistrian University of Athens, 1 Rimini Str., Chaidari, Attiki, Greece.Department of Cardiology, General Hospital of Athens “G.Gennimatas”, Athens, GreeceColchicine’s medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine’s future potential applications.http://www.sciencedirect.com/science/article/pii/S2214750021001360ColchicineHistoryPharmacokineticsInflammationSafetyRepurposing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dimitrios A. Vrachatis Konstantinos A. Papathanasiou Sotiria G. Giotaki Konstantinos E. Iliodromitis Theodore G. Papaioannou Giulio G. Stefanini Michael Cleman Gerasimos Siasos Bernhard Reimers Alexandra Lansky Jean-Claude Tardif Spyridon G. Deftereos George Giannopoulos |
spellingShingle |
Dimitrios A. Vrachatis Konstantinos A. Papathanasiou Sotiria G. Giotaki Konstantinos E. Iliodromitis Theodore G. Papaioannou Giulio G. Stefanini Michael Cleman Gerasimos Siasos Bernhard Reimers Alexandra Lansky Jean-Claude Tardif Spyridon G. Deftereos George Giannopoulos Repurposing colchicine’s journey in view of drug-to-drug interactions. A review Toxicology Reports Colchicine History Pharmacokinetics Inflammation Safety Repurposing |
author_facet |
Dimitrios A. Vrachatis Konstantinos A. Papathanasiou Sotiria G. Giotaki Konstantinos E. Iliodromitis Theodore G. Papaioannou Giulio G. Stefanini Michael Cleman Gerasimos Siasos Bernhard Reimers Alexandra Lansky Jean-Claude Tardif Spyridon G. Deftereos George Giannopoulos |
author_sort |
Dimitrios A. Vrachatis |
title |
Repurposing colchicine’s journey in view of drug-to-drug interactions. A review |
title_short |
Repurposing colchicine’s journey in view of drug-to-drug interactions. A review |
title_full |
Repurposing colchicine’s journey in view of drug-to-drug interactions. A review |
title_fullStr |
Repurposing colchicine’s journey in view of drug-to-drug interactions. A review |
title_full_unstemmed |
Repurposing colchicine’s journey in view of drug-to-drug interactions. A review |
title_sort |
repurposing colchicine’s journey in view of drug-to-drug interactions. a review |
publisher |
Elsevier |
series |
Toxicology Reports |
issn |
2214-7500 |
publishDate |
2021-01-01 |
description |
Colchicine’s medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine’s future potential applications. |
topic |
Colchicine History Pharmacokinetics Inflammation Safety Repurposing |
url |
http://www.sciencedirect.com/science/article/pii/S2214750021001360 |
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