Immunotherapy against Prion Disease
The term “prion disease” encompasses a group of neurodegenerative diseases affecting both humans and animals. Currently, there is no effective therapy and all forms of prion disease are invariably fatal. Because of (a) the outbreak of bovine spongiform encephalopathy in cattle an...
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doaj-ec3e8485f75e4ac496e160dcbe827b392020-11-25T01:41:51ZengMDPI AGPathogens2076-08172020-03-019321610.3390/pathogens9030216pathogens9030216Immunotherapy against Prion DiseaseYue Ma0Jiyan Ma1Center for Neurodegenerative Science, Van Andel Institute, 333 Bostwick Avenue N.E., Grand Rapids, MI 49503, USACenter for Neurodegenerative Science, Van Andel Institute, 333 Bostwick Avenue N.E., Grand Rapids, MI 49503, USAThe term “prion disease” encompasses a group of neurodegenerative diseases affecting both humans and animals. Currently, there is no effective therapy and all forms of prion disease are invariably fatal. Because of (a) the outbreak of bovine spongiform encephalopathy in cattle and variant Creutzfeldt−Jakob disease in humans; (b) the heated debate about the prion hypothesis; and (c) the availability of a natural prion disease in rodents, the understanding of the pathogenic process in prion disease is much more advanced compared to that of other neurodegenerative disorders, which inspired many attempts to develop therapeutic strategies against these fatal diseases. In this review, we focus on immunotherapy against prion disease. We explain our rationale for immunotherapy as a plausible therapeutic choice, review previous trials using either active or passive immunization, and discuss potential strategies for overcoming the hurdles in developing a successful immunotherapy. We propose that immunotherapy is a plausible and practical therapeutic strategy and advocate more studies in this area to develop effective measures to control and treat these devastating disorders.https://www.mdpi.com/2076-0817/9/3/216prion diseaseprpimmunotherapyvaccineantibody |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yue Ma Jiyan Ma |
spellingShingle |
Yue Ma Jiyan Ma Immunotherapy against Prion Disease Pathogens prion disease prp immunotherapy vaccine antibody |
author_facet |
Yue Ma Jiyan Ma |
author_sort |
Yue Ma |
title |
Immunotherapy against Prion Disease |
title_short |
Immunotherapy against Prion Disease |
title_full |
Immunotherapy against Prion Disease |
title_fullStr |
Immunotherapy against Prion Disease |
title_full_unstemmed |
Immunotherapy against Prion Disease |
title_sort |
immunotherapy against prion disease |
publisher |
MDPI AG |
series |
Pathogens |
issn |
2076-0817 |
publishDate |
2020-03-01 |
description |
The term “prion disease” encompasses a group of neurodegenerative diseases affecting both humans and animals. Currently, there is no effective therapy and all forms of prion disease are invariably fatal. Because of (a) the outbreak of bovine spongiform encephalopathy in cattle and variant Creutzfeldt−Jakob disease in humans; (b) the heated debate about the prion hypothesis; and (c) the availability of a natural prion disease in rodents, the understanding of the pathogenic process in prion disease is much more advanced compared to that of other neurodegenerative disorders, which inspired many attempts to develop therapeutic strategies against these fatal diseases. In this review, we focus on immunotherapy against prion disease. We explain our rationale for immunotherapy as a plausible therapeutic choice, review previous trials using either active or passive immunization, and discuss potential strategies for overcoming the hurdles in developing a successful immunotherapy. We propose that immunotherapy is a plausible and practical therapeutic strategy and advocate more studies in this area to develop effective measures to control and treat these devastating disorders. |
topic |
prion disease prp immunotherapy vaccine antibody |
url |
https://www.mdpi.com/2076-0817/9/3/216 |
work_keys_str_mv |
AT yuema immunotherapyagainstpriondisease AT jiyanma immunotherapyagainstpriondisease |
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