Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission
Depressive disorders represent a major public health concern and display a continuously rising prevalence. Importantly, a large proportion of patients develops aversive side effects and/or does not respond properly to conventional antidepressants. These issues highlight the need to identify further...
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doaj-ec41c836caee4a19970adaa4e894b3f72021-03-12T00:00:15ZengMDPI AGNutrients2072-66432021-03-011390490410.3390/nu13030904Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic NeurotransmissionCamille Monchaux De Oliveira0Line Pourtau1Sylvie Vancassel2Camille Pouchieu3Lucile Capuron4David Gaudout5Nathalie Castanon6INRAE, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, FranceActiv’Inside, 33750 Beychac-et-Caillau, FranceINRAE, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, FranceActiv’Inside, 33750 Beychac-et-Caillau, FranceINRAE, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, FranceActiv’Inside, 33750 Beychac-et-Caillau, FranceINRAE, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, FranceDepressive disorders represent a major public health concern and display a continuously rising prevalence. Importantly, a large proportion of patients develops aversive side effects and/or does not respond properly to conventional antidepressants. These issues highlight the need to identify further therapeutic strategies, including nutritional approaches using natural plant extracts with known beneficial impacts on health. In that context, growing evidence suggests that saffron could be a particularly promising candidate. This preclinical study aimed therefore to test its antidepressant-like properties in mice and to decipher the underlying mechanisms by focusing on monoaminergic neurotransmission, due to its strong implication in mood disorders. For this purpose, the behavioral and neurobiochemical impact of a saffron extract, Safr’Inside™ (6.5 mg/kg <i>per os</i>) was measured in naïve mice. Saffron extract reduced depressive-like behavior in the forced swim test. This behavioral improvement was associated with neurobiological modifications, particularly changes in serotonergic and dopaminergic neurotransmission, suggesting that Safr’Inside™ may share common targets with conventional pharmacological antidepressants. This study provides useful information on the therapeutic relevance of nutritional interventions with saffron extracts to improve management of mood disorders.https://www.mdpi.com/2072-6643/13/3/904mood disordersnutritional interventionssaffron extractSafr’Inside<sup>TM</sup>depressive-like behaviormonoaminergic neurotransmission |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Camille Monchaux De Oliveira Line Pourtau Sylvie Vancassel Camille Pouchieu Lucile Capuron David Gaudout Nathalie Castanon |
spellingShingle |
Camille Monchaux De Oliveira Line Pourtau Sylvie Vancassel Camille Pouchieu Lucile Capuron David Gaudout Nathalie Castanon Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission Nutrients mood disorders nutritional interventions saffron extract Safr’Inside<sup>TM</sup> depressive-like behavior monoaminergic neurotransmission |
author_facet |
Camille Monchaux De Oliveira Line Pourtau Sylvie Vancassel Camille Pouchieu Lucile Capuron David Gaudout Nathalie Castanon |
author_sort |
Camille Monchaux De Oliveira |
title |
Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission |
title_short |
Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission |
title_full |
Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission |
title_fullStr |
Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission |
title_full_unstemmed |
Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission |
title_sort |
saffron extract-induced improvement of depressive-like behavior in mice is associated with modulation of monoaminergic neurotransmission |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-03-01 |
description |
Depressive disorders represent a major public health concern and display a continuously rising prevalence. Importantly, a large proportion of patients develops aversive side effects and/or does not respond properly to conventional antidepressants. These issues highlight the need to identify further therapeutic strategies, including nutritional approaches using natural plant extracts with known beneficial impacts on health. In that context, growing evidence suggests that saffron could be a particularly promising candidate. This preclinical study aimed therefore to test its antidepressant-like properties in mice and to decipher the underlying mechanisms by focusing on monoaminergic neurotransmission, due to its strong implication in mood disorders. For this purpose, the behavioral and neurobiochemical impact of a saffron extract, Safr’Inside™ (6.5 mg/kg <i>per os</i>) was measured in naïve mice. Saffron extract reduced depressive-like behavior in the forced swim test. This behavioral improvement was associated with neurobiological modifications, particularly changes in serotonergic and dopaminergic neurotransmission, suggesting that Safr’Inside™ may share common targets with conventional pharmacological antidepressants. This study provides useful information on the therapeutic relevance of nutritional interventions with saffron extracts to improve management of mood disorders. |
topic |
mood disorders nutritional interventions saffron extract Safr’Inside<sup>TM</sup> depressive-like behavior monoaminergic neurotransmission |
url |
https://www.mdpi.com/2072-6643/13/3/904 |
work_keys_str_mv |
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