EFFECT OF THE BASIS THERAPY ON THE CONNECTIVE TISSUE TERN-OVER LEVEL IN CHILDREN WITH BRONCHIAL ASTHMA

• Main Authors: L.V. Ryabova, M.K. Ermakova, N.R. Kapustina
• Format: Article
• Language: English
• Published: Paediatrician Publishers, LLC 2009-06-01
• Series: Pediatričeskaâ Farmakologiâ
• Online Access: https://pf.spr-journal.ru/jour/article/view/930

Bronchial asthma is a chronic inflammatory disease and it belongs to the widely spread allergies among children. The inflammation leads to the disorder in the exchange reactions within the main substance of the connective tissue. This research analyzes peculiarities of the tern-over in lisomal enzymes — α-mannosidase, β-mannosidase and sialic acids against the backdrop of different types of the basis therapy of bronchial asthma in children in the outpatient conditions. They basic group of patients was made up of 27 children, undergoing a combined basic therapy. The patients of second group (n = 43) were administered the inhalant glucocorticosteroids. The third group (n = 38) ho did not receive any basis therapy. The control group included 30 healthy children. The results of the investigations showed that the adequate basic therapy of bronchial asthma in children have a favorable effect on the connective tissue biopolymers tern over.Key words: bronchial asthma, basis therapy, inhalant glucocorticosteroids, connective tissue, α-mannosidase, β-mannosidase, sialic acids children.