Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals
Abstract Background Infections caused by third generation cephalosporin-resistant Enterobacteriaceae (3GCREB) are an increasing healthcare problem. We aim to describe the 3GCREB infection incidence and compare it to prevalence upon admission. In addition, we aim to describe infections caused by 3GCR...
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doaj-ec4b06021f4a430db2c23b0aabf7b00c2020-11-25T00:26:17ZengBMCAntimicrobial Resistance and Infection Control2047-29942018-12-01711910.1186/s13756-018-0452-8Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitalsAnna M. Rohde0Janine Zweigner1Miriam Wiese-Posselt2Frank Schwab3Michael Behnke4Axel Kola5Birgit Obermann6Johannes K.-M. Knobloch7Susanne Feihl8Christiane Querbach9Friedemann Gebhardt10Alexander Mischnik11Vera Ihle12Wiebke Schröder13Sabina Armean14Silke Peter15Evelina Tacconelli16Axel Hamprecht17Harald Seifert18Maria J. G. T. Vehreschild19Winfried V. Kern20Petra Gastmeier21on behalf of the DZIF-ATHOS study group22German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)German Center for Infection Research (DZIF)Abstract Background Infections caused by third generation cephalosporin-resistant Enterobacteriaceae (3GCREB) are an increasing healthcare problem. We aim to describe the 3GCREB infection incidence and compare it to prevalence upon admission. In addition, we aim to describe infections caused by 3GCREB, which are also carbapenem resistant (CRE). Methods In 2014–2015, we performed prospective 3GCREB surveillance in clinically relevant patient specimens (screening specimens excluded). Infections counted as hospital-acquired (HAI) when the 3GCREB was detected after the third day following admission, otherwise as community-acquired infection (CAI). Results Of 578,420 hospitalized patients under surveillance, 3367 had a 3GCREB infection (0.58%). We observed a similar 3GCREB CAI and HAI incidence (0.28 and 0.31 per 100 patients, respectively). The most frequent pathogen was 3GCR E. coli, in CAI and HAI (0.15 and 0.12 per 100 patients). We observed a CRE CAI incidence of 0.006 and a HAI incidence of 0.008 per 100 patients (0.014 per 1000 patient days). Conclusions Comparing the known 3GCREB admission prevalence of the participating hospitals (9.5%) with the percentage of patients with a 3GCREB infection (0.58%), we conclude the prevalence of 3GCREB in university hospitals to be about 16 times higher than suggested when only patients with 3GCREB infections are considered. Moreover, we find the HAI and CAI incidence caused by CRE in Germany to be relatively low.http://link.springer.com/article/10.1186/s13756-018-0452-8FluoroquinoloneCarbapenemGram-negativeESBLEnterobacter spp.Klebsiella spp. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna M. Rohde Janine Zweigner Miriam Wiese-Posselt Frank Schwab Michael Behnke Axel Kola Birgit Obermann Johannes K.-M. Knobloch Susanne Feihl Christiane Querbach Friedemann Gebhardt Alexander Mischnik Vera Ihle Wiebke Schröder Sabina Armean Silke Peter Evelina Tacconelli Axel Hamprecht Harald Seifert Maria J. G. T. Vehreschild Winfried V. Kern Petra Gastmeier on behalf of the DZIF-ATHOS study group |
spellingShingle |
Anna M. Rohde Janine Zweigner Miriam Wiese-Posselt Frank Schwab Michael Behnke Axel Kola Birgit Obermann Johannes K.-M. Knobloch Susanne Feihl Christiane Querbach Friedemann Gebhardt Alexander Mischnik Vera Ihle Wiebke Schröder Sabina Armean Silke Peter Evelina Tacconelli Axel Hamprecht Harald Seifert Maria J. G. T. Vehreschild Winfried V. Kern Petra Gastmeier on behalf of the DZIF-ATHOS study group Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals Antimicrobial Resistance and Infection Control Fluoroquinolone Carbapenem Gram-negative ESBL Enterobacter spp. Klebsiella spp. |
author_facet |
Anna M. Rohde Janine Zweigner Miriam Wiese-Posselt Frank Schwab Michael Behnke Axel Kola Birgit Obermann Johannes K.-M. Knobloch Susanne Feihl Christiane Querbach Friedemann Gebhardt Alexander Mischnik Vera Ihle Wiebke Schröder Sabina Armean Silke Peter Evelina Tacconelli Axel Hamprecht Harald Seifert Maria J. G. T. Vehreschild Winfried V. Kern Petra Gastmeier on behalf of the DZIF-ATHOS study group |
author_sort |
Anna M. Rohde |
title |
Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals |
title_short |
Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals |
title_full |
Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals |
title_fullStr |
Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals |
title_full_unstemmed |
Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals |
title_sort |
incidence of infections due to third generation cephalosporin-resistant enterobacteriaceae - a prospective multicentre cohort study in six german university hospitals |
publisher |
BMC |
series |
Antimicrobial Resistance and Infection Control |
issn |
2047-2994 |
publishDate |
2018-12-01 |
description |
Abstract Background Infections caused by third generation cephalosporin-resistant Enterobacteriaceae (3GCREB) are an increasing healthcare problem. We aim to describe the 3GCREB infection incidence and compare it to prevalence upon admission. In addition, we aim to describe infections caused by 3GCREB, which are also carbapenem resistant (CRE). Methods In 2014–2015, we performed prospective 3GCREB surveillance in clinically relevant patient specimens (screening specimens excluded). Infections counted as hospital-acquired (HAI) when the 3GCREB was detected after the third day following admission, otherwise as community-acquired infection (CAI). Results Of 578,420 hospitalized patients under surveillance, 3367 had a 3GCREB infection (0.58%). We observed a similar 3GCREB CAI and HAI incidence (0.28 and 0.31 per 100 patients, respectively). The most frequent pathogen was 3GCR E. coli, in CAI and HAI (0.15 and 0.12 per 100 patients). We observed a CRE CAI incidence of 0.006 and a HAI incidence of 0.008 per 100 patients (0.014 per 1000 patient days). Conclusions Comparing the known 3GCREB admission prevalence of the participating hospitals (9.5%) with the percentage of patients with a 3GCREB infection (0.58%), we conclude the prevalence of 3GCREB in university hospitals to be about 16 times higher than suggested when only patients with 3GCREB infections are considered. Moreover, we find the HAI and CAI incidence caused by CRE in Germany to be relatively low. |
topic |
Fluoroquinolone Carbapenem Gram-negative ESBL Enterobacter spp. Klebsiella spp. |
url |
http://link.springer.com/article/10.1186/s13756-018-0452-8 |
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