Osteoarthritis-Related Inflammation Blocks TGF-β’s Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region

Osteoarthritis-Related Inflammation Blocks TGF-β’s Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region

Osteoarthritis (OA) is a degenerative joint disease characterized by irreversible cartilage damage, inflammation and altered chondrocyte phenotype. Transforming growth factor-β (TGF-β) signaling via SMAD2/3 is crucial for blocking hypertrophy. The post-translational modifications of these SMAD prote...

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Bibliographic Details
Main Authors: Nathalie Thielen, Margot Neefjes, Renske Wiegertjes, Guus van den Akker, Elly Vitters, Henk van Beuningen, Esmeralda Blaney Davidson, Marije Koenders, Peter van Lent, Fons van de Loo, Arjan van Caam, Peter van der Kraan
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
TGF-β
osteoarthritis
cartilage
SMAD2/3 signaling
linker modifications
inflammation
Online Access:https://www.mdpi.com/1422-0067/22/15/8124

Internet

https://www.mdpi.com/1422-0067/22/15/8124

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