Biogenesis, cellular effects, and biomarker value of circHIPK3
Abstract Competing endogenous RNAs (ceRNAs) can indirectly regulate gene expression by competitively binding to microRNA(miRNA) through miRNA response elements (MREs) to affect miRNA-induced gene regulation, which is of great biological significance. Among them, circular RNA (circRNA) has become a h...
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doaj-ec69335ac0b846a68ce10ec78716ef8a2021-05-11T14:52:39ZengBMCCancer Cell International1475-28672021-05-0121111310.1186/s12935-021-01956-2Biogenesis, cellular effects, and biomarker value of circHIPK3Yihan Fu0Hong Sun1Obstetrics and Gynecology Hospital, Fudan UniversityObstetrics and Gynecology Hospital, Fudan UniversityAbstract Competing endogenous RNAs (ceRNAs) can indirectly regulate gene expression by competitively binding to microRNA(miRNA) through miRNA response elements (MREs) to affect miRNA-induced gene regulation, which is of great biological significance. Among them, circular RNA (circRNA) has become a hotspot due to its highest binding capacity. A specific circRNA discussed in this review, circHIPK3, has been studied for its biological characteristics, function, cellular effects and its relationship with tumors and various diseases. Here, we review the recent researches about circHIPK3 in detail and aim to elucidate accurate conclusions from them. These circHIPK3-miRNAs-mRNA pathways will further advance the application of circHIPK3 in diseases development, early diagnosis and gene targeting therapy.https://doi.org/10.1186/s12935-021-01956-2CircHIPK3MiRNAs spongeBiomarkerCancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yihan Fu Hong Sun |
spellingShingle |
Yihan Fu Hong Sun Biogenesis, cellular effects, and biomarker value of circHIPK3 Cancer Cell International CircHIPK3 MiRNAs sponge Biomarker Cancer |
author_facet |
Yihan Fu Hong Sun |
author_sort |
Yihan Fu |
title |
Biogenesis, cellular effects, and biomarker value of circHIPK3 |
title_short |
Biogenesis, cellular effects, and biomarker value of circHIPK3 |
title_full |
Biogenesis, cellular effects, and biomarker value of circHIPK3 |
title_fullStr |
Biogenesis, cellular effects, and biomarker value of circHIPK3 |
title_full_unstemmed |
Biogenesis, cellular effects, and biomarker value of circHIPK3 |
title_sort |
biogenesis, cellular effects, and biomarker value of circhipk3 |
publisher |
BMC |
series |
Cancer Cell International |
issn |
1475-2867 |
publishDate |
2021-05-01 |
description |
Abstract Competing endogenous RNAs (ceRNAs) can indirectly regulate gene expression by competitively binding to microRNA(miRNA) through miRNA response elements (MREs) to affect miRNA-induced gene regulation, which is of great biological significance. Among them, circular RNA (circRNA) has become a hotspot due to its highest binding capacity. A specific circRNA discussed in this review, circHIPK3, has been studied for its biological characteristics, function, cellular effects and its relationship with tumors and various diseases. Here, we review the recent researches about circHIPK3 in detail and aim to elucidate accurate conclusions from them. These circHIPK3-miRNAs-mRNA pathways will further advance the application of circHIPK3 in diseases development, early diagnosis and gene targeting therapy. |
topic |
CircHIPK3 MiRNAs sponge Biomarker Cancer |
url |
https://doi.org/10.1186/s12935-021-01956-2 |
work_keys_str_mv |
AT yihanfu biogenesiscellulareffectsandbiomarkervalueofcirchipk3 AT hongsun biogenesiscellulareffectsandbiomarkervalueofcirchipk3 |
_version_ |
1721443944449966080 |