CD40 and Tolerance Induction
CD40 is recognized as a member of tumor necrosis factor receptor super family. It is expressed by the immune and non-immune cells. Its interaction with CD40 ligand (CD154) brings about a regulatory effect on the cellular and humoral immunity. The pathway of CD40-CD154 is influential in various di...
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Tehran University of Medical Sciences
2012-03-01
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doaj-ec69a76b9f924ca29affd2e8a80d27fe2020-11-25T04:11:59ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492012-03-01111325CD40 and Tolerance InductionMohammad Hossein Karimi0Ali Akbar Pourfathollah1Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Immunology, Faculty of Basic Medical Sciences, Tarbiat Modares University, Tehran, Iran CD40 is recognized as a member of tumor necrosis factor receptor super family. It is expressed by the immune and non-immune cells. Its interaction with CD40 ligand (CD154) brings about a regulatory effect on the cellular and humoral immunity. The pathway of CD40-CD154 is influential in various diseases. Investigations on such diseases have revealed dimensional mechanisms whereby this route intensifies host protection. Moreover, through these mechanisms, pathogens subvert the signaling of the CD40, conditions in which the CD40–CD154 pathway promotes disease and also through the relevant modulation for immunotherapy. This review focuses on the role of CD40–CD40L (CD154) interactions in dendritic cells (DCs) regulation, tolerogenic dendritic cells, role of CD40 in autoimmune disease, allograft rejection and induction of tolerance by down regulation of CD40. According to these roles, it is assumed that CD40 is a functional molecule in the pathologies of conditions like autoimmune diseases and allograft rejection caused by activated T and B cells. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/325CD40Tolerance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Hossein Karimi Ali Akbar Pourfathollah |
spellingShingle |
Mohammad Hossein Karimi Ali Akbar Pourfathollah CD40 and Tolerance Induction Iranian Journal of Allergy, Asthma and Immunology CD40 Tolerance |
author_facet |
Mohammad Hossein Karimi Ali Akbar Pourfathollah |
author_sort |
Mohammad Hossein Karimi |
title |
CD40 and Tolerance Induction |
title_short |
CD40 and Tolerance Induction |
title_full |
CD40 and Tolerance Induction |
title_fullStr |
CD40 and Tolerance Induction |
title_full_unstemmed |
CD40 and Tolerance Induction |
title_sort |
cd40 and tolerance induction |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Allergy, Asthma and Immunology |
issn |
1735-1502 1735-5249 |
publishDate |
2012-03-01 |
description |
CD40 is recognized as a member of tumor necrosis factor receptor super family. It is expressed by the immune and non-immune cells. Its interaction with CD40 ligand (CD154) brings about a regulatory effect on the cellular and humoral immunity. The pathway of CD40-CD154 is influential in various diseases. Investigations on such diseases have revealed dimensional mechanisms whereby this route intensifies host protection. Moreover, through these mechanisms, pathogens subvert the signaling of the CD40, conditions in which the CD40–CD154 pathway promotes disease and also through the relevant modulation for immunotherapy.
This review focuses on the role of CD40–CD40L (CD154) interactions in dendritic cells (DCs) regulation, tolerogenic dendritic cells, role of CD40 in autoimmune disease, allograft rejection and induction of tolerance by down regulation of CD40. According to these roles, it is assumed that CD40 is a functional molecule in the pathologies of conditions like autoimmune diseases and allograft rejection caused by activated T and B cells.
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topic |
CD40 Tolerance |
url |
https://ijaai.tums.ac.ir/index.php/ijaai/article/view/325 |
work_keys_str_mv |
AT mohammadhosseinkarimi cd40andtoleranceinduction AT aliakbarpourfathollah cd40andtoleranceinduction |
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1724416303615180800 |