Pharmacists’ role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre study
Objectives: Antimicrobial stewardship (AMS) teams around the world include pharmacists; however, their impact is relatively unknown. This study aimed to explore the relationship between pharmacists’ actions and antibiotic consumption. Methods: Hospital pharmacists involved in the French antibiotic c...
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doaj-ec6e535a43504759bc3a178de765509f2021-05-20T07:48:34ZengElsevierJournal of Global Antimicrobial Resistance2213-71652020-03-0120131134Pharmacists’ role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre studyClément Ourghanlian0Nathanaël Lapidus1Marie Antignac2Christine Fernandez3Catherine Dumartin4Patrick Hindlet5AP-HP, Hôpital Henri Mondor, Pharmacie, F-94000, Créteil, France; Corresponding author at: Service Pharmacie, Hôpital Henri Mondor, 51 Avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique, IPLESP, F-75012, Paris, France; AP-HP, GH HUEP, Département de Santé Publique, F-75012, Paris, FranceAP-HP, GH HUEP, Pharmacie, F-75012, Paris, FranceSorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique, IPLESP, F-75012, Paris, France; AP-HP, GH HUEP, Pharmacie, F-75012, Paris, France; Univ Paris-Sud, Faculté de Pharmacie, Département de Pharmacie Clinique, F-92296, Châtenay-Malabry, FranceUniversité de Bordeaux, INSERM 1219, F-33000, Bordeaux, France; CHU de Bordeaux, Centre d’appui pour la Prévention des Infections Associées aux Soins Nouvelle-Aquitaine, F-33000, Bordeaux, FranceSorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique, IPLESP, F-75012, Paris, France; AP-HP, GH HUEP, Pharmacie, F-75012, Paris, France; Univ Paris-Sud, Faculté de Pharmacie, Département de Pharmacie Clinique, F-92296, Châtenay-Malabry, FranceObjectives: Antimicrobial stewardship (AMS) teams around the world include pharmacists; however, their impact is relatively unknown. This study aimed to explore the relationship between pharmacists’ actions and antibiotic consumption. Methods: Hospital pharmacists involved in the French antibiotic consumption surveillance network (ATB-Raisin) were invited to participate in a retrospective observational multicentre study. Collected data were: the previous year’s (2016) antibiotic consumption expressed in daily defined dose per 1000 patient-days; AMS measures, including pharmacist-specific actions; and use of a computerised prescription order entry (CPOE) system. Associations between antibiotic consumption and AMS measures were assessed by linear regression, after adjustment for hospital activities. Results: Annual data for 2016 from 77 hospitals (7 260 000 bed-days in 24 000 beds) were analysed. Pharmacists were involved in AMS programs in 73% of hospitals, and were the antibiotic advisor in 25%. Pharmaceutical review of prescriptions was organised in almost all hospitals (97%). The univariable analysis identified five measures associated with lower overall antibiotic consumption: CPOE use (if >80% of prescriptions or 100%), pharmaceutical review (if >80% of beds or 100%) and the antibiotic advisor being a pharmacist (P = 0.04, P = 0.004 and P = 0.003, respectively). In the multivariable analysis, two explanatory variables were significantly and independently associated with a lower overall antibiotic consumption: the antibiotic advisor being a pharmacist and a pharmaceutical review covering all beds (–19.9% [–31.6%; –8.1%], P = 0.002 and –18.3% [–34.0%; –2.6%], P = 0.03, respectively). Conclusions: Antibiotic consumption was lower when the antibiotic advisor was a pharmacist and when the pharmaceutical team reviewed all prescriptions. These results highlight that actions initiated by pharmacists have a positive impact and should be supported.http://www.sciencedirect.com/science/article/pii/S2213716519301754Antimicrobial stewardshipAntibiotic consumptionPharmacist |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Clément Ourghanlian Nathanaël Lapidus Marie Antignac Christine Fernandez Catherine Dumartin Patrick Hindlet |
spellingShingle |
Clément Ourghanlian Nathanaël Lapidus Marie Antignac Christine Fernandez Catherine Dumartin Patrick Hindlet Pharmacists’ role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre study Journal of Global Antimicrobial Resistance Antimicrobial stewardship Antibiotic consumption Pharmacist |
author_facet |
Clément Ourghanlian Nathanaël Lapidus Marie Antignac Christine Fernandez Catherine Dumartin Patrick Hindlet |
author_sort |
Clément Ourghanlian |
title |
Pharmacists’ role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre study |
title_short |
Pharmacists’ role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre study |
title_full |
Pharmacists’ role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre study |
title_fullStr |
Pharmacists’ role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre study |
title_full_unstemmed |
Pharmacists’ role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre study |
title_sort |
pharmacists’ role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: an observational multicentre study |
publisher |
Elsevier |
series |
Journal of Global Antimicrobial Resistance |
issn |
2213-7165 |
publishDate |
2020-03-01 |
description |
Objectives: Antimicrobial stewardship (AMS) teams around the world include pharmacists; however, their impact is relatively unknown. This study aimed to explore the relationship between pharmacists’ actions and antibiotic consumption. Methods: Hospital pharmacists involved in the French antibiotic consumption surveillance network (ATB-Raisin) were invited to participate in a retrospective observational multicentre study. Collected data were: the previous year’s (2016) antibiotic consumption expressed in daily defined dose per 1000 patient-days; AMS measures, including pharmacist-specific actions; and use of a computerised prescription order entry (CPOE) system. Associations between antibiotic consumption and AMS measures were assessed by linear regression, after adjustment for hospital activities. Results: Annual data for 2016 from 77 hospitals (7 260 000 bed-days in 24 000 beds) were analysed. Pharmacists were involved in AMS programs in 73% of hospitals, and were the antibiotic advisor in 25%. Pharmaceutical review of prescriptions was organised in almost all hospitals (97%). The univariable analysis identified five measures associated with lower overall antibiotic consumption: CPOE use (if >80% of prescriptions or 100%), pharmaceutical review (if >80% of beds or 100%) and the antibiotic advisor being a pharmacist (P = 0.04, P = 0.004 and P = 0.003, respectively). In the multivariable analysis, two explanatory variables were significantly and independently associated with a lower overall antibiotic consumption: the antibiotic advisor being a pharmacist and a pharmaceutical review covering all beds (–19.9% [–31.6%; –8.1%], P = 0.002 and –18.3% [–34.0%; –2.6%], P = 0.03, respectively). Conclusions: Antibiotic consumption was lower when the antibiotic advisor was a pharmacist and when the pharmaceutical team reviewed all prescriptions. These results highlight that actions initiated by pharmacists have a positive impact and should be supported. |
topic |
Antimicrobial stewardship Antibiotic consumption Pharmacist |
url |
http://www.sciencedirect.com/science/article/pii/S2213716519301754 |
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